概述

  • 产品名称Anti-MRP6抗体
    参阅全部 MRP6 一抗
  • 描述
    小鼠单克隆抗体to MRP6
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 831-931 of Human MRP6 with tag (NP_001162).

  • 阳性对照
    • Recombinant fragment of human MRP6.

性能

应用

Our Abpromise guarantee covers the use of ab54826 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution. Detection limit for recombinant tagged ABCC6 is approximately 0.03ng/ml if used as a capture antibody.
WB 1/500 - 1/1000. Detects a band of approximately 37 kDa (predicted molecular weight: 164 kDa).

靶标

  • 功能May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).
  • 组织特异性Expressed in kidney and liver. Very low expression in other tissues.
  • 疾病相关Defects in ABCC6 are the cause of pseudoxanthoma elasticum (PXE) [MIM:264800]. PXE is a disorder characterized by calcification of elastic fibers in skin, arteries and retina that results in dermal lesions with associated laxity and loss of elasticity, arterial insufficiency and retinal hemorrhages leading to macular degeneration. PXE is caused in the overwhelming majority of cases by homozygous or compound heterozygous mutations in the ABCC6 gene (autosomal recessive PXE). Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype (autosomal dominant PXE).
  • 序列相似性Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
  • 细胞定位Membrane. Localized to the basolateral membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ABC34 antibody
    • Abcc6 antibody
    • Anthracycline resistance-associated protein antibody
    • ARA antibody
    • ATP binding cassette sub family C (CFTR/MRP) member 6 antibody
    • ATP binding cassette sub family C member 6 antibody
    • ATP-binding cassette sub-family C member 6 antibody
    • EST349056 antibody
    • MLP1 antibody
    • MOAT E antibody
    • MOAT-E antibody
    • MOATE antibody
    • MRP 6 antibody
    • MRP6 antibody
    • MRP6_HUMAN antibody
    • Multi-specific organic anion transporter E antibody
    • Multidrug resistance associated protein 6 antibody
    • Multidrug resistance-associated protein 6 antibody
    • multispecific organic anion transporter E antibody
    • PXE antibody
    • PXE1 antibody
    • URG7 antibody
    • URG7 protein antibody
    see all

Anti-MRP6 antibody 图像

  • Anti-MRP6 antibody (ab54826) at 1/500 dilution + Recombinant fragment of human MRP6 at 0.2 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/5000 dilution

    Predicted band size : 164 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)

Anti-MRP6 antibody (ab54826)参考文献

ab54826 has not yet been referenced specifically in any publications.

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