概述

  • 产品名称Anti-MRP2抗体
    参阅全部 MRP2 一抗
  • 描述
    兔多克隆抗体to MRP2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Rabbit, Horse, Guinea pig, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within internal amino acids 651-700 (TIQDVNLDIK PGQLVAVVGT VGSGKSSLIS AMLGEMENVH GHITIKGSIA) of Mouse MRP2 (NP_038834).

  • 阳性对照
    • Mouse Spleen Lysate.

性能

应用

Our Abpromise guarantee covers the use of ab110740 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 174 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
  • 组织特异性Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.
  • 疾病相关Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.
  • 序列相似性Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ABC30 antibody
    • abcC2 antibody
    • ATP binding cassette sub family C (CFTR/MRP) member 2 antibody
    • ATP binding cassette subfamily C member 2 antibody
    • ATP-binding cassette sub-family C member 2 antibody
    • Canalicular multidrug resistance protein antibody
    • Canalicular multispecific organic anion transporter 1 antibody
    • CMOAT antibody
    • CMOAT1 antibody
    • cMRP antibody
    • DJS antibody
    • KIAA1010 antibody
    • MRP 2 antibody
    • MRP2_HUMAN antibody
    • Multidrug resistance associated protein 2 antibody
    • Multidrug resistance-associated protein 2 antibody
    see all

Anti-MRP2 antibody 图像

  • Anti-MRP2 antibody (ab110740) at 1 µg/ml + Mouse Spleen Lysate at 10 µg

    Predicted band size : 174 kDa

Anti-MRP2 antibody (ab110740)参考文献

This product has been referenced in:
  • Canet MJ  et al. Renal xenobiotic transporter expression is altered in multiple experimental models of nonalcoholic steatohepatitis. Drug Metab Dispos 43:266-72 (2015). Read more (PubMed: 25488932) »

See 1 Publication for this product

Product Wall

Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Mouse Tissue sections (Liver)
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Sodium Citrate, pH 6.0
Permeabilization No
Specification Liver
Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 25°C
Fixative 10% Neutral Buffered Formalin
Username

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Verified customer

提交于 Nov 30 2015

Thank you for confirming those details.
As requested, I have generated a discount code for the anti-MRP2 antibody (ab110740) to be tested with canine protein. The discount code is as follows:
Discount code: xxxxxxxx Expiration date: 23rd Nove...

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Thank you for contacting us and your interest in our products.
The immunogens used to raise the antibodies ab3373 and ab110740 against MRP2 both share higher than 85% homology with the canine protein. The ab3373 immunogen shares 88% homology and t...

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Thank you very much for your inquiry and your patience while waiting for our answer.

I have inquired with the laboratories of the polyclonal antibodies, whether the immunogen sequence is conserved with the pig sequence. This would then provid...

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Thank you for contacting Abcam regarding ab110740. I have confirmed that unfortunately, there are no available references for this antibody. I would like to inform you that all of our products are guaranteed under our Abpromise such that we are happy t...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"