概述

  • 产品名称Anti-MRP1抗体[IU2H10]
    参阅全部 MRP1 一抗
  • 描述
    小鼠单克隆抗体[IU2H10] to MRP1
  • 特异性This antibody is specific for MRP1 protein.
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Recombinant fragment: MALRGFCSAD GSDPLWDWNV TWNTSNPDFT KCF, corresponding to amino acids 1-33 of Human MRP1

性能

应用

Our Abpromise guarantee covers the use of ab32574 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Predicted molecular weight: 172 kDa. There may be a lower MW band that is a degradation product.
ICC/IF Use at an assay dependent dilution.

靶标

  • 功能Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
  • 组织特异性Lung, testis and peripheral blood mononuclear cells.
  • 序列相似性Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ABC 29 antibody
    • ABC29 antibody
    • ABCC 1 antibody
    • ABCC antibody
    • Abcc1 antibody
    • ATP binding cassette sub family C (CFTR/MRP) member 1 antibody
    • ATP binding cassette sub-family C member 1 antibody
    • ATP-binding cassette sub-family C member 1 antibody
    • DKFZp686N04233 antibody
    • DKFZp781G125 antibody
    • GS X antibody
    • GSX antibody
    • Leukotriene C(4) transporter antibody
    • LTC4 transporter antibody
    • MRP 1 antibody
    • MRP antibody
    • MRP1_HUMAN antibody
    • Multidrug resistance associated protein 1 antibody
    • Multidrug resistance protein antibody
    • Multidrug resistance-associated protein 1 antibody
    • Multiple drug resistance associated protein antibody
    • Multiple drug resistance protein 1 antibody
    see all

Anti-MRP1 antibody [IU2H10] 图像

  • All lanes : Anti-MRP1 antibody [IU2H10] (ab32574)

    Lane 1 : Vector-transfected HEK293 cells
    Lane 2 : MRP1-transfected cells, prep1
    Lane 3 : MRP1-transfected cells, prep2 (the lower band is a degradation product)


    Predicted band size : 172 kDa

Anti-MRP1 antibody [IU2H10] (ab32574)参考文献

This product has been referenced in:
  • Abu N  et al. Flavokawain B induced cytotoxicity in two breast cancer cell lines, MCF-7 and MDA-MB231 and inhibited the metastatic potential of MDA-MB231 via the regulation of several tyrosine kinases In vitro. BMC Complement Altern Med 16:86 (2016). WB . Read more (PubMed: 26922065) »
  • Li L  et al. Overexpression of ß-Catenin Induces Cisplatin Resistance in Oral Squamous Cell Carcinoma. Biomed Res Int 2016:5378567 (2016). WB ; Human . Read more (PubMed: 27529071) »

See all 8 Publications for this product

Product Wall

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For ab108312, you could use human fetal liver (ab29890), JAR, 293T (ab95494), HepG2 (ab7900) or human placenta (ab29745) lysates as a positive control.

For ab32574, you could consider using MRP-1 trans...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"