这个 快线抗体 还未被充份测试和鉴定,因此它受制于相关的 使用条款

Anti-MRF抗体- Oligodendrocyte Marker (ab85464)

概述

  • 产品名称
    Anti-MRF抗体- Oligodendrocyte Marker
    参阅全部 MRF 一抗
  • 描述
    兔多克隆抗体to MRF - Oligodendrocyte Marker

    该产品是 快线抗体,通过亲和纯化得到。对抗原肽有高灵敏度及特异性(ELISA测试)。 Read the terms of use »

  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Rabbit
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 1100 to the C-terminus of Human MRF.

  • 阳性对照
    • This antibody gave a positive signal in the following Mouse tissue lysates: Brain day 0; Embryonic brain E14; Embryonic brain E16.

性能

应用

Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA). Fast track terms of use

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 123 kDa (predicted molecular weight: 123 kDa).

靶标

  • 功能
    Transcription regulator required for expression of central nervous system (CNS) myelin genes such as MBP and MOG, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Probably acts as a transcription factor that directly binds DNA and activates expression of CNS myelin genes.
  • 组织特异性
    Expressed in lung, ARPE-19 cell line, brainstem, uterus and, to a lesser extent, in basal ganglion and liver. Weakly expressed in cerebellum and retina.
  • 序列相似性
    Belongs to the MRF family.
    Contains 1 NDT80 DNA-binding domain.
  • 结构域
    A transmembrane region is predicted by sequence analysis tools. However, the protein is nuclear and probably acts as a transcription factor. It is therefore unclear whether the predicted transmembrane region is a hydrophobic region that does not insert into membranes or whether it is a real transmembrane region that may be cleaved when acting as transcription regulator.
  • 细胞定位
    Membrane. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C11orf9 antibody
    • Chromosome 11 open reading frame 9 antibody
    • GM1804 antibody
    • GM98 antibody
    • KIAA0954 antibody
    • MGC10781 antibody
    • MRF antibody
    • MRF_HUMAN antibody
    • Myelin gene regulatory factor antibody
    • Ndt80 antibody
    see all

图片

This Fast-Track antibody is not yet fully characterised. These images represent inconclusive preliminary data.

  • All lanes : Anti-MRF antibody - Oligodendrocyte Marker (ab85464) at 1/250 dilution

    Lane 1 : Mouse brain tissue lysate - total protein (0 days) (ab7188)
    Lane 2 : E14 Mouse Embryo Brain Tissue Lysate
    Lane 3 : E16 Ms Embryo Brain Tissue Lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 123 kDa
    Observed band size : 123 kDa
    Additional bands at : 22 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 4 minutes

实验方案

文献

ab85464 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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