概述

  • 产品名称Anti-MRC2抗体
    参阅全部 MRC2 一抗
  • 描述
    小鼠单克隆抗体to MRC2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 105-215 of Human MRC2

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 同种型IgG2a
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab56883 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs).
    • 组织特异性Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.
    • 序列相似性Contains 8 C-type lectin domains.
      Contains 1 fibronectin type-II domain.
      Contains 1 ricin B-type lectin domain.
    • 结构域C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner.
      Fibronectin type-II domain mediates collagen-binding.
      Ricin B-type lectin domain contacts with the second C-type lectin domain.
    • 翻译后修饰N-glycosylated.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C-type lectin domain family 13 member E antibody
      • C-type mannose receptor 2 antibody
      • CD 280 antibody
      • CD280 antibody
      • CD280 antigen antibody
      • CLEC 13E antibody
      • CLEC13E antibody
      • ENDO 180 antibody
      • ENDO180 antibody
      • Endocytic receptor (macrophage mannose receptor family) antibody
      • Endocytic receptor 180 antibody
      • FLJ35911 antibody
      • KIAA0709 antibody
      • Macrophage mannose receptor 2 antibody
      • Mannose receptor C type 2 antibody
      • MRC 2 antibody
      • MRC2 antibody
      • MRC2_HUMAN antibody
      • UPAR-associated protein antibody
      • UPARAP antibody
      • Urokinase plasminogen activator receptor associated protein antibody
      • Urokinase receptor associated protein antibody
      • Urokinase receptor-associated protein antibody
      • Urokinase-type plasminogen activator receptor-associated protein antibody
      see all

    Anti-MRC2 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56883 MRC2 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

    Anti-MRC2 antibody (ab56883)参考文献

    ab56883 has not yet been referenced specifically in any publications.

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