概述

  • 产品名称Anti-MPP5抗体
    参阅全部 MPP5 一抗
  • 描述
    小鼠单克隆抗体to MPP5
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: LDLNSSMRLK KLAQIPPKTG IDNPMFDTEE GIVLESPHYA VKILEIEDLF SSLKHIQHTL VDSQSQEDIS LLLQLVQNKD FQNAFKIHNA ITVHMNKAS, corresponding to amino acids 79-178 of Human MPP5

性能

应用

Our Abpromise guarantee covers the use of ab56405 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton.
    • 组织特异性Expressed in the retina (at protein level).
    • 序列相似性Belongs to the MAGUK family.
      Contains 1 guanylate kinase-like domain.
      Contains 2 L27 domains.
      Contains 1 PDZ (DHR) domain.
      Contains 1 SH3 domain.
    • 结构域The L27 domain 1 functions in targeting to the tight junctions by binding to INADL.
      The PDZ domain binds to the C-terminus of SC6A1.
    • 细胞定位Cell membrane. Endomembrane system. Cell junction > tight junction. Localized to the tight junctions of epithelial cells and a subset of intracellular vesicles. In the retina, detected at the outer limiting membrane (OLM), apical to the adherens junction (AJ), where it colocalizes with CRB1. Colocalizes with MPP1 in the retina at the outer limiting membrane (OLM). Localized to the Purkinje cell body and axon.
    • Information by UniProt
    • 数据库链接
    • 别名
      • FLJ12615 antibody
      • MAGUK p55 subfamily member 5 antibody
      • Membrane protein palmitoylated 5 antibody
      • MPP 5 antibody
      • MPP5 antibody
      • MPP5_HUMAN antibody
      • PALS 1 antibody
      • PALS1 antibody
      • Protein associated with Lin-7 antibody
      • Stardust (Drosophila) antibody
      • Stardust antibody
      see all

    Anti-MPP5 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56405 MPP5 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-MPP5 antibody (ab56405)参考文献

    ab56405 has not yet been referenced specifically in any publications.

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