概述

  • 产品名称Anti-MOX1抗体
    参阅全部 MOX1 一抗
  • 描述
    兔多克隆抗体to MOX1
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cow, Dog
  • 免疫原

    Synthetic peptide derived from a region between residues 42-96 of Human MOX1.

  • 阳性对照
    • Jurkat cell lysate. Human liver cells. Human stomach cells.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab23279 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.2 - 2 µg/ml. Detects a band of approximately 32 kDa (predicted molecular weight: 28 kDa).Can be blocked with MOX1 peptide (ab199250). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use at an assay dependent concentration.

靶标

  • 功能Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
  • 疾病相关Klippel-Feil syndrome 2, autosomal recessive
  • 序列相似性Contains 1 homeobox DNA-binding domain.
  • 细胞定位Nucleus. Cytoplasm. Localizes predominantly in the nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Homeobox protein MOX-1 antibody
    • MEOX1 antibody
    • MEOX1_HUMAN antibody
    • Mesenchyme homeo box 1 antibody
    • Mesenchyme homeobox 1 antibody
    • MOX 1 antibody
    • MOX1 antibody
    see all

Anti-MOX1 antibody 图像

  • Anti-MOX1 antibody (ab23279) at 0.5 µg/ml + Jurkat cell lysate

    Secondary
    HRP conjugated anti-Rabbit IgG should be diluted in 1/50,000 - 100,000

    Predicted band size : 28 kDa
    Observed band size : 32 kDa (why is the actual band size different from the predicted?)
  • ab23279, at 4.0 - 8.0ug/ml staining human MOX1 in (human Liver) by Immunohistochemistry,Paraffin embedded tissue. Positive cells marked by arrows are hepatocytes. magnification 400 x.
  • ab23279, at 4.0 - 8.0ug/ml dilution, staining human MOX1 in human stomach by Immunohistochemistry, Paraffin embedded tissue. Cells with positive staining, marked by arrows, are Epithelial cells of Fundic Gland. Magnification 400 x.

Anti-MOX1 antibody (ab23279)参考文献

ab23279 has not yet been referenced specifically in any publications.

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