概述

描述

  • 性质Synthetic

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技术指标

Our Abpromise guarantee covers the use of ab38371 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-REC8 antibody (ab38372)

  • 形式Liquid
  • 补充说明

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

常规信息

  • 别名
    • Cohesin Rec8p
    • Human homolog of rad21 S. pombe
    • Meiotic recombination and sister chromatid cohesion phosphoprotein of the rad21p family
    • Meiotic recombination protein REC8 homolog
    • Meiotic recombination protein REC8-like 1
    • rec8
    • REC8 homolog (yeast)
    • REC8 like 1
    • REC8_HUMAN
    • Rec8p
    • Recombination and sister chromatid cohesion protein homolog
    see all
  • 功能Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.
  • 组织特异性Expressed in testis and thymus.
  • 序列相似性Belongs to the rad21 family.
  • 翻译后修饰Phosphorylated.
  • 细胞定位Nucleus. Chromosome. In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II.
  • Information by UniProt

Mouse REC8 peptide (ab38371)参考文献

ab38371 has not yet been referenced specifically in any publications.

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