小鼠Ionotropic Glutamate receptor 2肽(ab25708)

概述

  • 产品名称小鼠Ionotropic Glutamate receptor 2肽

描述

  • 性质Synthetic

技术指标

Our Abpromise guarantee covers the use of ab25708 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-Ionotropic Glutamate receptor 2 antibody (ab20673)

  • 形式Liquid
  • 补充说明

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

常规信息

  • 别名
    • AMPA 2
    • AMPA selective glutamate receptor 2
    • AMPA-selective glutamate receptor 2
    • AMPA2
    • GluA2
    • GLUR 2
    • GLUR B
    • GluR K2
    • GluR-2
    • GluR-B
    • GluR-K2
    • GLUR2
    • GLURB
    • Glutamate receptor 2
    • Glutamate receptor ionotropic
    • Glutamate receptor ionotropic AMPA 2
    • Gria2
    • GRIA2_HUMAN
    • HBGR2
    see all
  • 功能Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
  • 序列相似性Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.
  • 翻译后修饰Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.
  • 细胞定位Cell membrane. Endoplasmic reticulum membrane. Cell junction > synapse > postsynaptic cell membrane. Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression.
  • Information by UniProt

Mouse Ionotropic Glutamate receptor 2 peptide (ab25708)参考文献

ab25708 has not yet been referenced specifically in any publications.

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The ab20673has not been tested on human samples yet, but is thought to be working as the homology is high. Please let me know if you would like to test this on your own asI could offer you our AbTrial discount.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"