概述
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产品名称小鼠FLIP多肽
参阅全部 FLIP 蛋白酶
描述
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性质Synthetic
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氨基酸序列
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种属Mouse
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序列DKVYAWNSGVSSKEKYS Amino acids 449 to 465 of human mFLIP (1,2)
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氨基酸449 to 465
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相关产品
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Corresponding Antibody
技术指标
Our Abpromise guarantee covers the use of ab8456 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
Blocking - Blocking peptide for Anti-FLIP antibody (ab8422)
Western blot
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形式Liquid
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Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
PBS with 0.1% BSA 0.02% sodium azide pH7.2
常规信息
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别名
- c FLIP
- c FLIPL
- c FLIPR
see all -
功能Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
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组织特异性Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
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序列相似性Belongs to the peptidase C14A family.
Contains 2 DED (death effector) domains. -
结构域The caspase domain lacks the active sites residues involved in catalysis.
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翻译后修饰Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12.
- Information by UniProt
文献
ab8456 has not yet been referenced specifically in any publications.
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"