Anti-MCT1/Monocarboxylic acid transporter 1抗体(ab90582)
Key features and details
- Mouse polyclonal to MCT1/Monocarboxylic acid transporter 1
- Suitable for: ICC/IF, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-MCT1/Monocarboxylic acid transporter 1抗体
参阅全部 MCT1/Monocarboxylic acid transporter 1 一抗 -
描述
小鼠多克隆抗体to MCT1/Monocarboxylic acid transporter 1 -
宿主
Mouse -
经测试应用
适用于: ICC/IF, WBmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein. This information is proprietary to Abcam and/or its suppliers.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab90582于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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ICC/IF | (2) |
Use a concentration of 10 µg/ml.
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WB | (3) |
Use a concentration of 1 µg/ml. Predicted molecular weight: 54 kDa.
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说明 |
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ICC/IF
Use a concentration of 10 µg/ml. |
WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 54 kDa. |
靶标
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功能
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. -
组织特异性
Widely expressed in normal and in cancer cells. -
疾病相关
Symptomatic deficiency in lactate transport
Familial hyperinsulinemic hypoglycemia 7 -
序列相似性
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 6566 Human
- Omim: 600682 Human
- SwissProt: P53985 Human
- Unigene: 75231 Human
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别名
- FLJ36745 antibody
- HHF7 antibody
- MCT 1 antibody
see all
图片
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All lanes : Anti-MCT1/Monocarboxylic acid transporter 1 antibody (ab90582) at 1 µg/ml
Lane 1 : Monocarboxylic acid transporter 1- transfected 293T cell lysate
Lane 2 : Non-transfected lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 54 kDa -
ab90582 at 10µg/ml staining Monocarboxylic acid transporter 1 in HeLa cells by Immunofluorescence.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (22)
ab90582 被引用在 22 文献中.
- Ippolito L et al. Lactate Rewires Lipid Metabolism and Sustains a Metabolic-Epigenetic Axis in Prostate Cancer. Cancer Res 82:1267-1282 (2022). PubMed: 35135811
- Sun Y et al. Prognostic implications of combined high expression of CD47 and MCT1 in breast cancer: a retrospective study during a 10-year period. Transl Cancer Res 11:29-42 (2022). PubMed: 35261882
- Peltanová B et al. mRNA Subtype of Cancer-Associated Fibroblasts Significantly Affects Key Characteristics of Head and Neck Cancer Cells. Cancers (Basel) 14:N/A (2022). PubMed: 35565415
- Longhitano L et al. Lactate Induces the Expressions of MCT1 and HCAR1 to Promote Tumor Growth and Progression in Glioblastoma. Front Oncol 12:871798 (2022). PubMed: 35574309
- Li L et al. Multi-omics profiling of collagen-induced arthritis mouse model reveals early metabolic dysregulation via SIRT1 axis. Sci Rep 12:11830 (2022). PubMed: 35821263