概述

  • 产品名称Anti-MOBK1B抗体
    参阅全部 MOBK1B 一抗
  • 描述
    兔多克隆抗体to MOBK1B
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Chicken, Cow, Pig, Chimpanzee, Zebrafish, Macaque Monkey, Orangutan
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human MOBK1B.

  • 阳性对照
    • This antibody gave a positive signal in the following Human tissue lysates: Adrenal Gland; Bone Marrow; Brain; Placenta; Skeletal Muscle; Testis; Thymus.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituent: PBS
    Note: Batches of this product that have a concentration < 1mg/ml may have BSA added as a stabilising agent. If you would like information about the formulation of a specific lot, please contact our scientific support team who will be happy to help.
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab110778 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 25 kDa).

靶标

  • 功能Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L.
  • 组织特异性Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver.
  • 序列相似性Belongs to the MOB1/phocein family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • B1, Mps One Binder kinase activator like 1B (yeast) antibody
    • C2orf6 antibody
    • Chromosome 2 open reading frame 6 antibody
    • FLJ10788 antibody
    • FLJ11595 antibody
    • MATS1 antibody
    • MOB kinase activator 1A antibody
    • MOB1 antibody
    • Mob1 alpha antibody
    • Mob1 homolog 1B antibody
    • MOB1 Mps One Binder homolog A antibody
    • MOB1 Mps One Binder kinase activator like 1B antibody
    • Mob1A antibody
    • MOB4B antibody
    • Mob4B protein antibody
    • MOBK1B antibody
    • Mobkl1b antibody
    • MOL1B_HUMAN antibody
    • Mps one binder kinase activator like 1B antibody
    • Mps one binder kinase activator-like 1B antibody
    • Protein Mob4B antibody
    see all

Anti-MOBK1B antibody 图像

  • All lanes : Anti-MOBK1B antibody (ab110778) at 1 µg/ml

    Lane 1 : Human adrenal normal tissue lysate - total protein (ab29249)
    Lane 2 : Bone Marrow (Human) Tissue Lysate - adult normal tissue
    Lane 3 : Human brain tissue lysate - total protein (ab29466)
    Lane 4 : Human placenta tissue lysate - total protein (ab29745)
    Lane 5 : Human skeletal muscle tissue lysate - total protein (ab29330)
    Lane 6 : Human testis tissue lysate - total protein (ab30257)
    Lane 7 : Human thymus tissue lysate - total protein (ab30146)

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 25 kDa
    Observed band size : 25 kDa
    Additional bands at : 30 kDa,44 kDa,70 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 4 minutes

Anti-MOBK1B antibody (ab110778)参考文献

ab110778 has not yet been referenced specifically in any publications.

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