概述

  • 产品名称Anti-MNDA抗体
    参阅全部 MNDA 一抗
  • 描述
    小鼠单克隆抗体to MNDA
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cynomolgus Monkey
  • 免疫原

    Synthetic peptide, corresponding to amino acids 311-408 of Human MNDA (NP_002423) with a proprietary tag.

  • 阳性对照
    • Human kidney tissue

性能

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应用

Our Abpromise guarantee covers the use of ab118371 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 3 µg/ml. Antigen retrieval is not essential but may optimise staining. Place sample in 1X citrate buffer (pH 6.0) in pressure cooker under 125oC for 4min and under 90oC for 45min.

靶标

  • 功能May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
  • 组织特异性Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast cells in some cases of acute myeloid Leukemia.
  • 序列相似性Contains 1 DAPIN domain.
    Contains 1 HIN-200 domain.
  • 结构域Its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding and a portion of this sequence is responsible for binding YY1.
  • 细胞定位Nucleus. Cytoplasm. Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MNDA antibody
    • MNDA_HUMAN antibody
    • Myeloid cell nuclear differentiation antigen antibody
    • OTTHUMP00000024384 antibody
    • PYHIN3 antibody
    see all

Anti-MNDA antibody 图像

  • Formalin-fixed, paraffin-embedded Human kidney tissue labelled with ab118371 at 3 µg/ml

Anti-MNDA antibody (ab118371)参考文献

ab118371 has not yet been referenced specifically in any publications.

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