概述

  • 产品名称Anti-MNAT1抗体
    参阅全部 MNAT1 一抗
  • 描述
    兔多克隆抗体to MNAT1
  • 特异性Detects endogenous levels of total MNAT1 protein.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide (Human) from an internal region

  • 阳性对照
    • Extracts from HeLa, HepG2 and 293 cells.

性能

应用

Our Abpromise guarantee covers the use of ab65125 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa).
ELISA 1/20000.

靶标

  • 功能Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
  • 组织特异性Highest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes.
  • 序列相似性Contains 1 RING-type zinc finger.
    Contains 1 UIM (ubiquitin-interacting motif) repeat.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MNAT 1 antibody
    • CAP35 antibody
    • CDK activating kinase assembly factor MAT1 antibody
    • CDK-activating kinase assembly factor MAT1 antibody
    • CDK7/cyclin H assembly factor antibody
    • CDK7/cyclin-H assembly factor antibody
    • Cyclin G1 interacting protein antibody
    • Cyclin-G1-interacting protein antibody
    • MAT1 antibody
    • MAT1_HUMAN antibody
    • Menage a trois 1 (CAK assembly factor) antibody
    • Menage a trois antibody
    • Menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) antibody
    • MNAT CDK activating kinase assembly factor 1 antibody
    • Mnat1 antibody
    • p35 antibody
    • p36 antibody
    • RING finger protein 66 antibody
    • RING finger protein MAT1 antibody
    • RNF66 antibody
    • TFB3 antibody
    see all

Anti-MNAT1 antibody 图像

  • All lanes : Anti-MNAT1 antibody (ab65125) at 1/500 dilution

    Lane 1 : HeLa cell extract
    Lane 2 : HepG2 cell extract
    Lane 3 : 293 cell extract
    Lane 4 : 293 cell extract with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 36 kDa
    Observed band size : 36 kDa
    Additional bands at : 28 kDa. We are unsure as to the identity of these extra bands.

Anti-MNAT1 antibody (ab65125)参考文献

ab65125 has not yet been referenced specifically in any publications.

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