Anti-MMP9抗体[SB15c] (HRP) (ab46728)

概述

  • 产品名称Anti-MMP9抗体[SB15c] (HRP)
    参阅全部 MMP9 一抗
  • 描述
    小鼠单克隆抗体[SB15c] to MMP9 (HRP)
  • 偶联物HRP
  • 特异性Ab46728 recognizes MMP9, but does not cross react with MMP1, MMP2 or MMP3.
  • 经测试应用适用于: ICC, WB, ELISA, IHC-Fr, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant human MMP9.

应用

Our Abpromise guarantee covers the use of ab46728 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 78 kDa. PubMed: 26998102
ELISA Use a concentration of 1 µg/ml.
IHC-Fr 1/1000 - 1/2000.
IHC-P Use at an assay dependent concentration.

靶标

  • 功能May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-
    -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
  • 组织特异性Produced by normal alveolar macrophages and granulocytes.
  • 疾病相关Intervertebral disc disease
    Metaphyseal anadysplasia 2
  • 序列相似性Belongs to the peptidase M10A family.
    Contains 3 fibronectin type-II domains.
    Contains 4 hemopexin repeats.
  • 结构域The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻译后修饰Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.
    N- and O-glycosylated.
  • 细胞定位Secreted, extracellular space, extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 82 kDa matrix metalloproteinase-9 antibody
    • 92 kDa gelatinase antibody
    • 92 kDa type IV collagenase antibody
    • CLG 4B antibody
    • CLG4B antibody
    • Collagenase Type 4 beta antibody
    • Collagenase type IV 92 KD antibody
    • EC 3.4.24.35 antibody
    • Gelatinase 92 KD antibody
    • Gelatinase B antibody
    • Gelatinase beta antibody
    • GelatinaseB antibody
    • GELB antibody
    • Macrophage gelatinase antibody
    • MANDP2 antibody
    • Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) antibody
    • Matrix Metalloproteinase 9 antibody
    • MMP 9 antibody
    • MMP-9 antibody
    • MMP9 antibody
    • MMP9_HUMAN antibody
    • Type V collagenase antibody
    see all

Anti-MMP9 antibody [SB15c] (HRP) 图像

  • Immunohistochemical analysis of paraffin embedded Human gastric cancer tissue labeling MMP9 with ab46728 at 1/1000 dilution

    Left:Mouse IgG-HRP isotype control

    Right:Sample MMP9 antibody

Anti-MMP9 antibody [SB15c] (HRP) (ab46728)参考文献

ab46728 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. Unfortunately, we have not tested this product to determine if it will also recognize the precursor to MMP-9 or not.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"