Anti-MMP9抗体, prediluted (ab75375)


  • 产品名称Anti-MMP9抗体, prediluted
    参阅全部 MMP9 一抗
  • 描述
    兔多克隆抗体to MMP9, prediluted
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Guinea pig, Human
    不与反应: Mouse, Rat, Cow
  • 免疫原

    A synthetic peptide derived from near the C terminal of human MMP9 protein.

  • 阳性对照
    • Human placenta tissue or breast carcinoma tissue.



Our Abpromise guarantee covers the use of ab75375 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明IHC-P: Ready to use.
    Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-
      -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
    • 组织特异性Produced by normal alveolar macrophages and granulocytes.
    • 疾病相关Intervertebral disc disease
      Metaphyseal anadysplasia 2
    • 序列相似性Belongs to the peptidase M10A family.
      Contains 3 fibronectin type-II domains.
      Contains 4 hemopexin repeats.
    • 结构域The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    • 翻译后修饰Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.
      N- and O-glycosylated.
    • 细胞定位Secreted, extracellular space, extracellular matrix.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 82 kDa matrix metalloproteinase-9 antibody
      • 92 kDa gelatinase antibody
      • 92 kDa type IV collagenase antibody
      • CLG 4B antibody
      • CLG4B antibody
      • Collagenase Type 4 beta antibody
      • Collagenase type IV 92 KD antibody
      • EC antibody
      • Gelatinase 92 KD antibody
      • Gelatinase B antibody
      • Gelatinase beta antibody
      • GelatinaseB antibody
      • GELB antibody
      • Macrophage gelatinase antibody
      • MANDP2 antibody
      • Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) antibody
      • Matrix Metalloproteinase 9 antibody
      • MMP 9 antibody
      • MMP-9 antibody
      • MMP9 antibody
      • MMP9_HUMAN antibody
      • Type V collagenase antibody
      see all

    Anti-MMP9 antibody, prediluted 图像

    • ab75375 (ready to use) staining MMP9 in human placenta by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue using peroxidase-conjugate and AEC chromogen. Note membrane staining of trophoblasts.

    Anti-MMP9 antibody, prediluted (ab75375)参考文献

    ab75375 has not yet been referenced specifically in any publications.

    Product Wall

    Abcam guarantees this product to work in the species/application used in this Abreview.
    Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample Human Tissue sections (placenta breast cancer)
    Specification placenta breast cancer
    Fixative Formaldehyde
    Antigen retrieval step Heat mediated - Buffer/Enzyme Used: citrate pH6.0, 20 min, 100C
    Permeabilization No

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    提交于 Oct 21 2011