概述

  • 产品名称Anti-MMP3抗体[SB14d]
    参阅全部 MMP3 一抗
  • 描述
    小鼠单克隆抗体[SB14d] to MMP3
  • 特异性This antibody does not cross react with human MMP1, MMP2 or MMP9.
  • 经测试应用适用于: ELISA, IHC-Fr, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length MMP3 (Human)

  • 阳性对照
    • Human colon carcinoma tissue.

应用

Our Abpromise guarantee covers the use of ab51202 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/3000 - 1/8000.
IHC-Fr Use a concentration of 2 µg/ml.
IHC-P Use at an assay dependent concentration.

靶标

  • 功能Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
  • 序列相似性Belongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • 结构域The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CHDS6 antibody
    • Matrix metalloproteinase 3 antibody
    • Matrix metalloproteinase-3 antibody
    • MGC126102 antibody
    • MGC126103 antibody
    • MGC126104 antibody
    • MMP 3 antibody
    • MMP-3 antibody
    • MMP3 antibody
    • MMP3_HUMAN antibody
    • Proteoglycanase antibody
    • SL-1 antibody
    • SL1 antibody
    • STMY antibody
    • STMY1 antibody
    • STR1 antibody
    • Stromelysin 1 antibody
    • Stromelysin-1 antibody
    • Transin 1 antibody
    • Transin-1 antibody
    see all

Anti-MMP3 antibody [SB14d] 图像

  • This image shows human colon carcinoma tissue stained with ab30844 at 5µg/ml.

Anti-MMP3 antibody [SB14d] (ab51202)参考文献

This product has been referenced in:
  • Gabay O  et al. Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model. Arthritis Rheum 65:159-66 (2013). IHC ; Mouse . Read more (PubMed: 23124828) »

See 1 Publication for this product

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