概述

  • 产品名称Anti-MMP28抗体
    参阅全部 MMP28 一抗
  • 描述
    小鼠单克隆抗体to MMP28
  • 经测试应用适用于: WB, Sandwich ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: LARGGLQVEP YYPRSLQDWG GIPEEVSGAL PRPDGSIIFF RDDRYWRLDQ AKLQATTSGR WATELPWMGC WHANSGSALF , corresponding to amino acids 441-521 of Human MMP28

性能

应用

Our Abpromise guarantee covers the use of ab57724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
Sandwich ELISA
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Can degrade casein. Could play a role in tissues homeostasis and repair.
    • 组织特异性Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and skin. Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytesis. Widely expressed in several carcinomas as well. Is up-regulated in response to injury in the skin.
    • 序列相似性Belongs to the peptidase M10A family.
      Contains 4 hemopexin-like domains.
    • 结构域The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    • 翻译后修饰The precursor is cleaved by a furin endopeptidase.
    • 细胞定位Secreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Epilysin antibody
      • Matrix metalloproteinase 28 antibody
      • Matrix metalloproteinase-28 antibody
      • MM 28 antibody
      • MM28 antibody
      • MMP 25 antibody
      • MMP 28 antibody
      • MMP-28 antibody
      • MMP25 antibody
      • MMP28 antibody
      • MMP28_HUMAN antibody
      see all

    Anti-MMP28 antibody 图像

    实验方案

    Anti-MMP28 antibody (ab57724)参考文献

    This product has been referenced in:
    • Slany A  et al. Cell characterization by proteome profiling applied to primary hepatocytes and hepatocyte cell lines Hep-G2 and Hep-3B. J Proteome Res 9:6-21 (2010). WB ; Human . Read more (PubMed: 19678649) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"