概述

  • 产品名称Anti-MMP19抗体, prediluted
    参阅全部 MMP19 一抗
  • 描述
    兔多克隆抗体to MMP19, prediluted
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    不与反应: Mouse, Rat
  • 免疫原

    Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (Human) (N terminal).

  • 阳性对照
    • Placenta.

性能

应用

Our Abpromise guarantee covers the use of ab15477 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: Ready to use for 10 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.
    • 组织特异性Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients.
    • 疾病相关May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients.
    • 序列相似性Belongs to the peptidase M10A family.
      Contains 4 hemopexin-like domains.
    • 结构域The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    • 翻译后修饰Activated by autolytic cleavage after Lys-97.
    • 细胞定位Secreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Matrix metalloproteinase 18 antibody
      • Matrix metalloproteinase 19 antibody
      • Matrix metalloproteinase RASI antibody
      • Matrix metalloproteinase-18 antibody
      • Matrix metalloproteinase-19 antibody
      • MMP 18 antibody
      • MMP 19 antibody
      • MMP-18 antibody
      • MMP-19 antibody
      • MMP18 antibody
      • MMP19 antibody
      • MMP19_HUMAN antibody
      • RASI 1 antibody
      • RASI antibody
      • RASI1 antibody
      see all

    Anti-MMP19 antibody, prediluted 图像

    • ab15477 staining MMP19 in human placenta by Immunohistochemistry (FFPE-sections).

    Anti-MMP19 antibody, prediluted (ab15477)参考文献

    This product has been referenced in:
    • Ishikawa A  et al. Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia. Neurosci Res 59:406-12 (2007). IHC-P ; Human . Read more (PubMed: 17889387) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"