概述

  • 产品名称Anti-MMP17抗体
    参阅全部 MMP17 一抗
  • 描述
    兔多克隆抗体to MMP17
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit
  • 免疫原

    Synthetic peptide:

    KDNNVEEGYPRPVSD

    conjugated to KLH, corresponding to amino acids 409-423 of Human MMP17

  • 阳性对照
    • Human Small Intestine tissue

性能

应用

Our Abpromise guarantee covers the use of ab115761 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1 - 1/1000.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
  • 组织特异性Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types.
  • 序列相似性Belongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • 结构域The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻译后修饰The precursor is cleaved by a furin endopeptidase.
  • 细胞定位Cell membrane. Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Matrix metalloproteinase 17 antibody
    • Matrix metalloproteinase 17 membrane inserted antibody
    • Matrix metalloproteinase-17 antibody
    • Membrane type 4 matrix metalloproteinase antibody
    • Membrane type matrix metalloproteinase 4 antibody
    • Membrane-type matrix metalloproteinase 4 antibody
    • Membrane-type-4 matrix metalloproteinase antibody
    • MMP 17 antibody
    • MMP-17 antibody
    • Mmp17 antibody
    • MMP17_HUMAN antibody
    • MT MMP 4 antibody
    • MT MMP4 antibody
    • MT-MMP 4 antibody
    • MT4 MMP antibody
    • MT4-MMP antibody
    • MT4MMP antibody
    • MTMMP 4 antibody
    • MTMMP4 antibody
    see all

Anti-MMP17 antibody 图像

  • Human Small Intestine (formalin-fixed, paraffin-embedded) stained with ab115761 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-MMP17 antibody (ab115761)参考文献

ab115761 has not yet been referenced specifically in any publications.

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