概述

  • 产品名称Anti-MMP16抗体
    参阅全部 MMP16 一抗
  • 描述
    兔多克隆抗体to MMP16
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthesized peptide derived from human MMP16.

  • 阳性对照
    • HepG2 cell extracts; Human brain tissue.

性能

应用

Our Abpromise guarantee covers the use of ab53145 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 57 kDa.
ELISA 1/10000.

靶标

  • 功能Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
  • 组织特异性Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.
  • 序列相似性Belongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • 发展阶段Expressed in tissues undergoing reconstruction. Present in fetal tissues, especially in brain. Expression seems to decline with advanced development.
  • 结构域The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻译后修饰The precursor is cleaved by a furin endopeptidase.
  • 细胞定位Cell membrane. Localized at the cell surface of melanoma cells and Secreted > extracellular space > extracellular matrix. Cell surface. Localized at the cell surface of melanoma cells.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C8orf57 antibody
    • DKFZp761D112 antibody
    • Matrix metalloproteinase 16 antibody
    • Matrix metalloproteinase-16 antibody
    • Membrane type 3 matrix metalloproteinase antibody
    • Membrane type matrix metalloproteinase 3 antibody
    • Membrane-type matrix metalloproteinase 3 antibody
    • Membrane-type-3 matrix metalloproteinase antibody
    • MMP 16 antibody
    • MMP-16 antibody
    • MMP-X2 antibody
    • MMP16 antibody
    • MMP16_HUMAN antibody
    • MT-MMP 3 antibody
    • MT-MMP2 antibody
    • MT-MMP3 antibody
    • MT3-MMP antibody
    • MT3MMP antibody
    • MTMMP2 antibody
    • MTMMP3 antibody
    • Putative transmembrane protein C8orf57 antibody
    see all

Anti-MMP16 antibody 图像

  • All lanes : Anti-MMP16 antibody (ab53145) at 1/500 dilution

    Lane 1 : HepG2 cell extract
    Lane 2 : HepG2 cell extract with immunizing peptide


    Predicted band size : 57 kDa

Anti-MMP16 antibody (ab53145)参考文献

This product has been referenced in:
  • Hadchouel A  et al. Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development. PLoS ONE 3:e3188 (2008). WB ; Human . Read more (PubMed: 18784838) »

See 1 Publication for this product

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