概述

  • 产品名称Anti-MMP15抗体
    参阅全部 MMP15 一抗
  • 描述
    兔多克隆抗体to MMP15
  • 特异性This antibody detects endogenous levels of total MMP15 protein.
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic MMP15 peptide (Human)

  • 阳性对照
    • Extracts from MDA-MB-435 cells

性能

应用

Our Abpromise guarantee covers the use of ab53770 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/10000.
WB 1/500 - 1/1000. Detects a band of approximately 76 kDa (predicted molecular weight: 76 kDa).

靶标

  • 功能Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.
  • 组织特异性Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.
  • 序列相似性Belongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • 结构域The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻译后修饰The precursor is cleaved by a furin endopeptidase.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AI503551 antibody
    • Matrix metallopeptidase 15 membrane inserted antibody
    • Matrix metalloproteinase 15 antibody
    • Matrix metalloproteinase-15 antibody
    • Membrane type 2 matrix metalloproteinase antibody
    • Membrane type matrix metalloproteinase 2 antibody
    • Membrane-type matrix metalloproteinase 2 antibody
    • Membrane-type-2 matrix metalloproteinase antibody
    • MMP 15 antibody
    • MMP-15 antibody
    • MMP15 antibody
    • MMP15_HUMAN antibody
    • MT MMP 2 antibody
    • MT-MMP 2 antibody
    • MT2 MMP antibody
    • MT2-MMP antibody
    • MT2MMP antibody
    • MTMMP 2 antibody
    • MTMMP2 antibody
    • SMCP 2 antibody
    • SMCP-2 antibody
    • SMCP2 antibody
    see all

Anti-MMP15 antibody 图像

  • All lanes : Anti-MMP15 antibody (ab53770) at 1/500 dilution

    Lane 1 : Extracts from MDA-MB-435 cells
    Lane 2 : Extracts from MDA-MB-435 cells, plus peptide


    Predicted band size : 76 kDa
    Observed band size : 76 kDa

Anti-MMP15 antibody (ab53770)参考文献

This product has been referenced in:
  • Silva EJ  et al. S100A8/A9 regulates MMP-2 expression and invasion and migration by carcinoma cells. Int J Biochem Cell Biol 55:279-87 (2014). WB ; Human . Read more (PubMed: 25236491) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"