Anti-MMP14抗体[LEM-2/63.1] (ab78738)


  • 产品名称
    参阅全部 MMP14 一抗
  • 描述
    小鼠单克隆抗体[LEM-2/63.1] to MMP14
  • 宿主
  • 经测试应用
    适用于: WB, IP, ELISA, IHC-Fr, Flow Cyt, Inhibition Assay, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Xenopus laevis, Macaque monkey
  • 免疫原

    Synthetic peptide: C-AEPWTVRNEDLNGNDI-C, corresponding to amino acids 218-233 within the catalytic domain of Human MMP14

  • 常规说明

    Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by June 2019 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause. We would recommend antibody ab51074 as a replacement.



Our Abpromise guarantee covers the use of ab78738 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 66 kDa.
IP Use at an assay dependent concentration.
ELISA Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration.

ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.


Inhibition Assay Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration.


  • 功能
    Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7.
  • 组织特异性
    Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.
  • 序列相似性
    Belongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • 结构域
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻译后修饰
    The precursor is cleaved by a furin endopeptidase.
  • 细胞定位
    Membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Matrix metallopeptidase 14 (membrane inserted) antibody
    • Matrix metalloproteinase 14 antibody
    • Matrix metalloproteinase-14 antibody
    • Membrane type 1 matrix metalloproteinase antibody
    • Membrane type 1 metalloprotease antibody
    • Membrane type matrix metalloproteinase 1 antibody
    • Membrane-type matrix metalloproteinase 1 antibody
    • Membrane-type-1 matrix metalloproteinase antibody
    • MMP 14 antibody
    • MMP X1 antibody
    • MMP-14 antibody
    • MMP-X1 antibody
    • Mmp14 antibody
    • MMP14_HUMAN antibody
    • MMPX1 antibody
    • MT MMP 1 antibody
    • MT-MMP 1 antibody
    • MT1 MMP antibody
    • MT1-MMP antibody
    • MT1MMP antibody
    • MTMMP 1 antibody
    • MTMMP1 antibody
    see all


This product has been referenced in:
  • Baldassarre T  et al. Endophilin A2 Promotes TNBC Cell Invasion and Tumor Metastasis. Mol Cancer Res 13:1044-55 (2015). Read more (PubMed: 25784716) »
  • Wali N  et al. Centrosomal BRCA2 is a target protein of membrane type-1 matrix metalloproteinase (MT1-MMP). Biochem Biophys Res Commun 443:1148-54 (2014). Read more (PubMed: 24384087) »

See all 7 Publications for this product


Thank you for contacting us. The paper that first describes the inhibition of MMP14 activity by this clone is the Galvez 2001 reference listed towards the bottom of the online datasheet, in figure 5. It also describes production of the clone and ot...

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