概述

  • 产品名称Anti-MMP13抗体[EP1263Y]
    参阅全部 MMP13 一抗
  • 描述
    兔单克隆抗体[EP1263Y] to MMP13
  • 经测试应用适用于: WBmore details
    不适用于: Flow Cyt,ICC/IF,IHC-Fr,IHC-P or IP
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide corresponding to residues near the C-terminus of human MMP13.

  • 阳性对照
    • HeLa cell lysate.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

     

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

应用

Our Abpromise guarantee covers the use of ab51072 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Detects a band of approximately 54 kDa (predicted molecular weight: 54 kDa).
  • 应用说明Is unsuitable for Flow Cyt,ICC/IF,IHC-Fr,IHC-P or IP.
  • 靶标

    • 功能Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process.
    • 组织特异性Seems to be specific to breast carcinomas.
    • 疾病相关Defects in MMP13 are the cause of spondyloepimetaphyseal dysplasia Missouri type (SEMD-MO) [MIM:602111]. A bone disease characterized by moderate to severe metaphyseal changes, mild epiphyseal involvement, rhizomelic shortening of the lower limbs with bowing of the femora and/or tibiae, coxa vara, genu varum and pear-shaped vertebrae in childhood. Epimetaphyseal changes improve with age.
      Defects in MMP13 are the cause of metaphyseal anadysplasia type 1 (MANDP1) [MIM:602111]. Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia.
    • 序列相似性Belongs to the peptidase M10A family.
      Contains 4 hemopexin-like domains.
    • 结构域The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    • 细胞定位Secreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CLG 3 antibody
      • CLG3 antibody
      • Collagenase 3 antibody
      • Collagenase3 antibody
      • MANDP1 antibody
      • Matrix metallopeptidase 13 (collagenase 3) antibody
      • Matrix Metalloproteinase 13 antibody
      • Matrix metalloproteinase-13 antibody
      • MMP 13 antibody
      • MMP-13 antibody
      • Mmp13 antibody
      • MMP13_HUMAN antibody
      see all

    Anti-MMP13 antibody [EP1263Y] 图像

    • Anti-MMP13 antibody [EP1263Y] (ab51072) at 1/500 dilution + HeLa cell lysate at 10 µg

      Secondary
      Goat anti-Rabbit HRP labeled at 1/2000 dilution

      Predicted band size : 54 kDa
      Observed band size : 54 kDa

    Anti-MMP13 antibody [EP1263Y] (ab51072)参考文献

    This product has been referenced in:
    • Li CM  et al. CCL17 Induces Trophoblast Migration and Invasion by Regulating Matrix Metalloproteinase and Integrin Expression in Human First-Trimester Placenta. Reprod Sci N/A:N/A (2014). Human . Read more (PubMed: 24401476) »
    • Ryu JH  et al. Hypoxia-inducible factor-2a is an essential catabolic regulator of inflammatory rheumatoid arthritis. PLoS Biol 12:e1001881 (2014). WB . Read more (PubMed: 24914685) »

    See all 4 Publications for this product

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