概述

  • 产品名称Anti-MMP13抗体
    参阅全部 MMP13 一抗
  • 描述
    兔多克隆抗体to MMP13
  • 特异性Based on Western blotting, the antibody reacts with human procollagenase-3. It does not react to a significant extent with human gelatinase A, gelatinase B, MT1-MMP, and the catalytic domains of MT2-MMP, MT3-MMP, MT4-MMP and MT5-MMP.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    This polyclonal antibody was raised against recombinant human procollagenase-3 expressed in insect cells

  • 常规说明MMP stands for "Matrix Metalloproteinase"

性能

应用

Our Abpromise guarantee covers the use of ab9128 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明ELISA: 1/2500 (PMID 18562219).
    WB: 1/2500 - 1/8000.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process.
    • 组织特异性Seems to be specific to breast carcinomas.
    • 疾病相关Defects in MMP13 are the cause of spondyloepimetaphyseal dysplasia Missouri type (SEMD-MO) [MIM:602111]. A bone disease characterized by moderate to severe metaphyseal changes, mild epiphyseal involvement, rhizomelic shortening of the lower limbs with bowing of the femora and/or tibiae, coxa vara, genu varum and pear-shaped vertebrae in childhood. Epimetaphyseal changes improve with age.
      Defects in MMP13 are the cause of metaphyseal anadysplasia type 1 (MANDP1) [MIM:602111]. Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia.
    • 序列相似性Belongs to the peptidase M10A family.
      Contains 4 hemopexin-like domains.
    • 结构域The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    • 细胞定位Secreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CLG 3 antibody
      • CLG3 antibody
      • Collagenase 3 antibody
      • Collagenase3 antibody
      • MANDP1 antibody
      • Matrix metallopeptidase 13 (collagenase 3) antibody
      • Matrix Metalloproteinase 13 antibody
      • Matrix metalloproteinase-13 antibody
      • MMP 13 antibody
      • MMP-13 antibody
      • Mmp13 antibody
      • MMP13_HUMAN antibody
      see all

    Anti-MMP13 antibody (ab9128)参考文献

    This product has been referenced in:
    • Jones SW  et al. Mitogen-activated protein kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology. Osteoarthritis Cartilage 17:124-31 (2009). ELISA ; Human . Read more (PubMed: 18562219) »
    • Jones SW  et al. The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13. Osteoarthritis Cartilage 17:464-72 (2009). Read more (PubMed: 19008124) »

    See all 2 Publications for this product

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