Anti-MMP11抗体[SL3.05] (Biotin) (ab79470)

概述

  • 产品名称Anti-MMP11抗体[SL3.05] (Biotin)
    参阅全部 MMP11 一抗
  • 描述
    小鼠单克隆抗体[SL3.05] to MMP11 (Biotin)
  • 偶联物Biotin
  • 经测试应用适用于: WB, IP, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant protein corresponding to the active form of Human MMP11

  • 阳性对照
    • WB: recombinant MMP11 protein IHC-P: Human placenta tissue
  • 常规说明Stable for 24 months when stored at 4°C.

性能

应用

Our Abpromise guarantee covers the use of ab79470 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IP
IHC-P
  • 应用说明IHC-P: Use at a concentration of 1 - 2 µg/ml. Antigen retrieval is not required.
    IP: Use at 2µg/mg of lysate. Native verified. Use protein G.
    WB: Use at a concentration of 0.5 - 1 µg/ml. Detects bands of approximately ~60kDa (latent), ~47kDa (active) and ~35kDa (degradation product).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May play an important role in the progression of epithelial malignancies.
    • 组织特异性Specifically expressed in stromal cells of breast carcinomas.
    • 序列相似性Belongs to the peptidase M10A family.
      Contains 4 hemopexin-like domains.
    • 结构域The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    • 翻译后修饰The precursor is cleaved by a furin endopeptidase.
    • 细胞定位Secreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Matrix Metalloproteinase 11 antibody
      • Matrix metalloproteinase-11 antibody
      • MMP-11 antibody
      • Mmp11 antibody
      • MMP11_HUMAN antibody
      • SL 3 antibody
      • SL-3 antibody
      • SL3 antibody
      • ST3 antibody
      • STMY3 antibody
      • Stromelysin 3 antibody
      • Stromelysin III antibody
      • Stromelysin-3 antibody
      see all

    Anti-MMP11 antibody [SL3.05] (Biotin) 图像

    • Immunohistochemistry analysis of formalin/fixed, paraffin-embedded Human placenta tissue, using the unconjugated version of ab79470, at 2.0µg/ml, with a peroxidase-conjugated secondary antibody and an AEC chromogen. Note cytoplasmic staining of trophoblasts.

    Anti-MMP11 antibody [SL3.05] (Biotin) (ab79470)参考文献

    ab79470 has not yet been referenced specifically in any publications.

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