概述

  • 产品名称Anti-MMP11抗体[SL3.05]
    参阅全部 MMP11 一抗
  • 描述
    小鼠单克隆抗体[SL3.05] to MMP11
  • 经测试应用适用于: WB, IP, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant protein corresponding to active form of human MMP11.

  • 阳性对照
    • Small intestine tissue.

性能

应用

Our Abpromise guarantee covers the use of ab85648 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 55 kDa.
IP Use at an assay dependent concentration.
IHC-P 1/200.

靶标

  • 功能May play an important role in the progression of epithelial malignancies.
  • 组织特异性Specifically expressed in stromal cells of breast carcinomas.
  • 序列相似性Belongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • 结构域The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻译后修饰The precursor is cleaved by a furin endopeptidase.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Matrix Metalloproteinase 11 antibody
    • Matrix metalloproteinase-11 antibody
    • MMP-11 antibody
    • Mmp11 antibody
    • MMP11_HUMAN antibody
    • SL 3 antibody
    • SL-3 antibody
    • SL3 antibody
    • ST3 antibody
    • STMY3 antibody
    • Stromelysin 3 antibody
    • Stromelysin III antibody
    • Stromelysin-3 antibody
    see all

Anti-MMP11 antibody [SL3.05] 图像

  • ab85648, at a 1/200 dilution, staining MMP11 in formalin fixed, paraffin embedded human small intestine tissue by Immunohistochemistry.

Anti-MMP11 antibody [SL3.05] (ab85648)参考文献

This product has been referenced in:
  • Meyer BS & Rademann J Extra- and Intracellular Imaging of Human Matrix Metalloprotease 11 (hMMP-11) with a Cell-penetrating FRET Substrate. J Biol Chem 287:37857-67 (2012). WB . Read more (PubMed: 22927434) »

See 1 Publication for this product

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