Anti-MMP1抗体[SB12e] (HRP) (ab46667)

概述

  • 产品名称Anti-MMP1抗体[SB12e] (HRP)
    参阅全部 MMP1 一抗
  • 描述
    小鼠单克隆抗体[SB12e] to MMP1 (HRP)
  • 偶联物HRP
  • 特异性Ab46667 recognizes MMP1; It does not cross react to MMP2, MMP3 or MMP9.
  • 经测试应用适用于: WB, IHC-Fr, IHC-P, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant human MMP1.

性能

应用

Our Abpromise guarantee covers the use of ab46667 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 54 kDa.
IHC-Fr 1/20 - 1/40.
IHC-P Use at an assay dependent dilution.
ELISA 1/1000 - 1/4000.

靶标

  • 功能Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
  • 序列相似性Belongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • 结构域There are two distinct domains in this protein; the catalytic N-terminal, and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases).
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻译后修饰Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 27 kDa interstitial collagenase antibody
    • CLG antibody
    • CLGN antibody
    • collagenase, fibroblast antibody
    • collagenase, interstitial antibody
    • Fibroblast collagenase antibody
    • Interstitial collagenase antibody
    • Matrix metallopeptidase 1 (interstitial collagenase) antibody
    • Matrix metalloprotease 1 antibody
    • Matrix Metalloproteinase 1 antibody
    • Matrix metalloproteinase-1 antibody
    • MMP 1 antibody
    • MMP-1 antibody
    • MMP1 antibody
    • MMP1_HUMAN antibody
    • OTTHUMP00000045866 antibody
    see all

Anti-MMP1 antibody [SB12e] (HRP) (ab46667)参考文献

ab46667 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your reply and for providing those details.

I have now emailed you a proforma regarding the purchase of ab46667 and ab64238.

As for detailed step by step protocols, we do not have any that would meet your requirements,...

Read More

Thank you for your reply.

I looked over the protocol that you sent and it looks to be OK with me. I had a colleague look at it aswell and they thought it was good too.

If there is anything else I can help you with, or if you have an...

Read More

Thank you for calling Abcam earlier today.

To be able to send a quote for the products you requested, please could you send me your shipping and billing address.

Once I get this information, I can send that quote out.

Also...

Read More

Thank you for your enquiry. This product is a licensed clone and the owner did not provide that information to us. Please let us know if we can further assist you.

Thank you for your enquiry. I have contacted the originator of the product but unfortunately, epitope mapping has not been done for this product. Therefore, we do not have any information on the epitope sequence. I am sorry I can't be of more as...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"