概述

  • 产品名称Anti-MMACHC抗体
    参阅全部 MMACHC 一抗
  • 描述
    兔多克隆抗体to MMACHC
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Recombinant fragment, corresponding to a sequence within amino acids 1-188 of Human MMACHC (NP_056321).

  • 阳性对照
    • 293T and Raji whole cell lysates; HeLa cells; A431, H1299, HeLaS3 and HepG2 cell lines

性能

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应用

Our Abpromise guarantee covers the use of ab96195 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 32 kDa.
ICC/IF 1/100 - 1/200.

靶标

  • 功能May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12).
  • 组织特异性Widely expressed. Expressed at higher level in fetal liver. Also expressed in spleen, lymph node, thymus and bone marrow. Weakly or not expressed in peripheral blood leukocytes.
  • 通路Cofactor biosynthesis; adenosylcobalamin biosynthesis.
  • 疾病相关Defects in MMACHC are the cause of methylmalonic aciduria and homocystinuria type cblC (MMACHC) [MIM:277400]. MMACHC is a disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl). Affected individuals may have developmental, hematologic, neurologic, metabolic, ophthalmologic, and dermatologic clinical findings. Although considered a disease of infancy or childhood, some individuals develop symptoms in adulthood.
  • 序列相似性Belongs to the MMACHC family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 1810037K07Rik antibody
    • BOS_3654 antibody
    • cblC antibody
    • DKFZp564I122 antibody
    • FLJ25671 antibody
    • Methylmalonic aciduria (cobalamin deficiency) cblC type with homocystinuria antibody
    • Methylmalonic aciduria and homocystinuria type C protein antibody
    • Methylmalonic aciduria and homocystinuria type C protein homolog antibody
    • MGC134307 antibody
    • MMAC_HUMAN antibody
    • MMACHC antibody
    • OTTHUMP00000009243 antibody
    • RP11 291L19.3 antibody
    • RP23-177C18.3 antibody
    see all

Anti-MMACHC antibody 图像

  • All lanes : Anti-MMACHC antibody (ab96195) at 1/1000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : Raji whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 32 kDa
  • ab96195, at 1/100 dilution, staining MMACHC in paraformaldehyde-fixed HeLa cells by Immunofluorescence. Lower image is merged with DNA probe.

Anti-MMACHC antibody (ab96195)参考文献

This product has been referenced in:
  • Fofou-Caillierez MB  et al. Interaction between methionine synthase isoforms and MMACHC: characterization in cblG-variant, cblG and cblC inherited causes of megaloblastic anaemia. Hum Mol Genet N/A:N/A (2013). Read more (PubMed: 23825108) »

See 1 Publication for this product

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