产品名称 Anti-MMACHC抗体 参阅全部 MMACHC 一抗
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MMACHC (AAH06122, 1 a.a. ~ 225 a.a) human protein.
MMACHC transfected 293T cell lysate.
存放说明 Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
存储溶液 Constituent: PBS
Concentration information loading...
纯度 Protein A purified
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Detects a band of approximately 27 kDa (predicted molecular weight: 32 kDa).
功能 May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12).
组织特异性 Widely expressed. Expressed at higher level in fetal liver. Also expressed in spleen, lymph node, thymus and bone marrow. Weakly or not expressed in peripheral blood leukocytes.
通路 Cofactor biosynthesis; adenosylcobalamin biosynthesis.
疾病相关 Defects in MMACHC are the cause of methylmalonic aciduria and homocystinuria type cblC (MMACHC) [MIM:277400]. MMACHC is a disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl). Affected individuals may have developmental, hematologic, neurologic, metabolic, ophthalmologic, and dermatologic clinical findings. Although considered a disease of infancy or childhood, some individuals develop symptoms in adulthood.
序列相似性 Belongs to the MMACHC family.
Information by UniProt
Anti-MMACHC antibody 图像
Western blot - MMACHC antibody (ab68678)
All lanes : Anti-MMACHC antibody (ab68678) at 1/500 dilution Lane 1 : MMACHC transfected 293T cell lysate Lane 2 : Non-transfected 293T cell lysate Lysates/proteins at 25 µg per lane. Secondary Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution Predicted band size : 32 kDa Observed band size : 27 kDa ( why is the actual band size different from the predicted?)
Anti-MMACHC antibody (ab68678)参考文献
has not yet been referenced specifically in any publications.
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