Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 63-92 of Human MMAA.
Mouse liver tissue lysate; human skeletal muscle tissue
Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
Preservative: 0.09% Sodium Azide
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Immunogen affinity purified
ab103459 is purified through a protein A column, followed by peptide affinity purification.
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/100 - 1/500. Predicted molecular weight: 47 kDa.
1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Probable GTPase. May function as chaperone. May be involved in the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis.
Widely expressed. Highest expression is observed in liver and skeletal muscle.
Cofactor biosynthesis; adenosylcobalamin biosynthesis.
Defects in MMAA are the cause of methylmalonic aciduria type cblA (MMAA) [MIM:251100]; also known as methylmalonic aciduria type A or vitamin B12-responsive methylmalonicaciduria of cblA complementation type. MMAA is a disorder of methylmalonate and cobalamin metabolism due to defective synthesis of adenosylcobalamin. Inheritance is autosomal recessive.
Belongs to the ArgK family.
Information by UniProt
Methylmalonic aciduria (cobalamin deficiency) cblA type antibody
Methylmalonic aciduria (cobalamin deficiency) type A antibody
Western blot - MMAA antibody (ab103459)
Anti-MMAA antibody (ab103459) at 1/100 dilution + Mouse liver tissue lysate at 35 µg
Predicted band size : 47 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MMAA antibody (ab103459)
ab103459, at 1/50 dilution, staining MMAA in formalin-fixed, paraffin-embedded human skeletal muscle tissue by Immunohistochemistry using a peroxidase conjugated secondary antibody and DAB staining.
has not yet been referenced specifically in any publications.
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