概述

  • 产品名称Anti-MMAA抗体
    参阅全部 MMAA 一抗
  • 描述
    兔多克隆抗体to MMAA
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 63-92 of Human MMAA.

  • 阳性对照
    • Mouse liver tissue lysate; human skeletal muscle tissue

性能

应用

Our Abpromise guarantee covers the use of ab103459 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 47 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Probable GTPase. May function as chaperone. May be involved in the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis.
  • 组织特异性Widely expressed. Highest expression is observed in liver and skeletal muscle.
  • 通路Cofactor biosynthesis; adenosylcobalamin biosynthesis.
  • 疾病相关Defects in MMAA are the cause of methylmalonic aciduria type cblA (MMAA) [MIM:251100]; also known as methylmalonic aciduria type A or vitamin B12-responsive methylmalonicaciduria of cblA complementation type. MMAA is a disorder of methylmalonate and cobalamin metabolism due to defective synthesis of adenosylcobalamin. Inheritance is autosomal recessive.
  • 序列相似性Belongs to the ArgK family.
  • 细胞定位Mitochondrion.
  • Information by UniProt
  • 数据库链接
  • 别名
    • cblA antibody
    • Methylmalonic aciduria (cobalamin deficiency) cblA type antibody
    • Methylmalonic aciduria (cobalamin deficiency) type A antibody
    • Methylmalonic aciduria type A protein antibody
    • Methylmalonic aciduria type A protein mitochondrial antibody
    • MGC120010 antibody
    • MGC120011 antibody
    • MGC120012 antibody
    • MGC120013 antibody
    • mitochondrial antibody
    • MMAA antibody
    • MMAA_HUMAN antibody
    • OTTHUMP00000220105 antibody
    see all

Anti-MMAA antibody 图像

  • Anti-MMAA antibody (ab103459) at 1/100 dilution + Mouse liver tissue lysate at 35 µg

    Predicted band size : 47 kDa
  • ab103459, at 1/50 dilution, staining MMAA in formalin-fixed, paraffin-embedded human skeletal muscle tissue by Immunohistochemistry using a peroxidase conjugated secondary antibody and DAB staining.

Anti-MMAA antibody (ab103459)参考文献

ab103459 has not yet been referenced specifically in any publications.

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