概述

  • 产品名称Anti-MLL5抗体
    参阅全部 MLL5 一抗
  • 描述
    兔多克隆抗体to MLL5
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 92-121 of Human MLL5 (NP_891847, Q8IZD2).

  • 阳性对照
    • HL60 cell line lysates.

性能

应用

Our Abpromise guarantee covers the use of ab123124 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 204 kDa.

靶标

  • 功能Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-induced granulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases.
  • 组织特异性Widely expressed in both adult and fetal tissues. Highest levels of expression observed in fetal thymus and kidney and in adult hematopoietic tissues, jejunum and cerebellum.
  • 序列相似性Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily.
    Contains 1 PHD-type zinc finger.
    Contains 1 SET domain.
  • 翻译后修饰O-glycosylation at Thr-440 in the SET domain by OGT is essential for the histone methyltransferase and the coactivator activity toward RARA in granulopoiesis. The absence of Thr-440 glycosylation in assays done in vitro may explain why some authors did not detected any histone methyltransferase activity for this protein.
  • 细胞定位Nucleus speckle. Absent from the nucleolus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HDCMC04P antibody
    • Histone lysine N methyltransferase MLL5 antibody
    • Histone-lysine N-methyltransferase MLL5 antibody
    • KMT2E antibody
    • Lysine N methyltransferase 2E antibody
    • Lysine N-methyltransferase 2E antibody
    • MGC70452 antibody
    • Mll5 antibody
    • MLL5_HUMAN antibody
    • Myeloid/lymphoid or mixed lineage leukemia 5 (trithorax homolog, Drosophila) antibody
    • Myeloid/lymphoid or mixed lineage leukemia 5 antibody
    • Myeloid/lymphoid or mixed lineage leukemia protein 5 antibody
    • Myeloid/lymphoid or mixed-lineage leukemia protein 5 antibody
    see all

Anti-MLL5 antibody 图像

  • Anti-MLL5 antibody (ab123124) at 1/100 dilution + HL60 cell line lysates at 35 µg

    Predicted band size : 204 kDa

Anti-MLL5 antibody (ab123124)参考文献

ab123124 has not yet been referenced specifically in any publications.

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