概述

  • 产品名称
  • 描述
    兔多克隆抗体to MLH3
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 1-282 of Human MLH3 (AAI12168).

  • 阳性对照
    • A549, HeLa, HepG2 and HCT116 whole cell lysates.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 20% Glycerol, 1.21% Tris, 0.75% Glycine
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab111942 is purified by antigen-affinity chromatography.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab111942 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 161 kDa.

靶标

  • 功能
    Probably involved in the repair of mismatches in DNA.
  • 组织特异性
    Ubiquitous.
  • 疾病相关
    Defects in MLH3 are the cause of hereditary non-polyposis colorectal cancer type 7 (HNPCC7) [MIM:614385]. Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world, and accounts for 15% of all colon cancers. Cancers in HNPCC originate within benign neoplastic polyps termed adenomas. Clinically, HNPCC is often divided into two subgroups. Type I: hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II: patients have an increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected.
    Defects in MLH3 are a cause of colorectal cancer (CRC) [MIM:114500].
  • 序列相似性
    Belongs to the DNA mismatch repair mutL/hexB family.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DNA mismatch repair protein Mlh3 antibody
    • HNPCC 7 antibody
    • HNPCC antibody
    • HNPCC7 antibody
    • MGC138372 antibody
    • Mismatch repair gene MLH 3 antibody
    • Mismatch repair gene MLH3 antibody
    • MLH 3 antibody
    • MLH3 antibody
    • MLH3_HUMAN antibody
    • MutL homolog 3 (E. coli) antibody
    • MutL homolog 3 antibody
    • MutL protein homolog 3 antibody
    • S240II117 antibody
    see all

图片

  • Anti-MLH3 antibody (ab111942) at 1/1000 dilution + HCT116 whole cell lysate at 30 µg

    Predicted band size : 161 kDa

实验方案

文献

ab111942 has not yet been referenced specifically in any publications.

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