Anti-MLF1 Interacting Protein/PBIP1抗体(ab117078)


  • 产品名称Anti-MLF1 Interacting Protein/PBIP1抗体
    参阅全部 MLF1 Interacting Protein/PBIP1 一抗
  • 描述
    兔多克隆抗体to MLF1 Interacting Protein/PBIP1
  • 经测试应用适用于: WB, IP, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Dog, Chimpanzee
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to amino acids surrounding Thr78 of Human MLF1 Interacting Protein/PBIP1. The immunogen peptide is phosphorylated at Thr78.

  • 阳性对照
    • Human Colon Adenocarcinoma tissue



Our Abpromise guarantee covers the use of ab117078 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/2000. Predicted molecular weight: 48 kDa.
IP Use at an assay dependent concentration.
IHC-P Use a concentration of 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF 1/100 - 1/500.


  • 功能Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.
  • 组织特异性Expressed at high levels in the testis, fetal liver, thymus, bone marrow and at lower levels in the lymph nodes, placenta, colon and spleen. Present in all cell lines examined, including B-cells, T-cells, epithelial cells and fibroblast cells. Expressed at high levels in glioblastoma cell lines.
  • 翻译后修饰Phosphorylated by PLK1 at Thr-78, creating a self-tethering site that specifically interacts with the polo-box domain of PLK1.
  • 细胞定位Cytoplasm. Nucleus. Chromosome > centromere > kinetochore. Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CENP U antibody
    • CENP-50 antibody
    • CENP-U antibody
    • CENP50 antibody
    • CENPU antibody
    • CENPU_HUMAN antibody
    • CENPU50 antibody
    • centromere protein of 50 kDa antibody
    • Centromere protein U antibody
    • FLJ23468 antibody
    • HHV8 LNAIP1 antibody
    • ICEN24 antibody
    • Interphase centromere complex protein 24 antibody
    • Kaposi Sarcoma Herpesvirus latent nuclear antigen interacting protein 1 antibody
    • KLIP-1 antibody
    • KLIP1 antibody
    • KSHV latent nuclear antigen interacting protein 1 antibody
    • KSHV latent nuclear antigen-interacting protein 1 antibody
    • KSHV LNAIP1 antibody
    • LNAIP 1 antibody
    • LNAIP-1 antibody
    • MLF1-interacting protein antibody
    • MLF1IP antibody
    • MLF1IP1 antibody
    • PBIP1 antibody
    • Polo-box-interacting protein 1 antibody
    see all

Anti-MLF1 Interacting Protein/PBIP1 antibody 图像

  • Human Colon Adenocarcinoma (formalin-fixed, paraffin-embedded) stained withab117078 at 20 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-MLF1 Interacting Protein/PBIP1 antibody (ab117078)参考文献

ab117078 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab117078.
Please use the links above to contact us or submit feedback about this product.