概述

  • 产品名称ML7
  • 描述
    Potent, selective myosin light chain kinase inhibitor
  • 生物学描述Potent and selective myosin light chain kinase inhibitor (MLCK) (Ki = 300 nM). Also inhibits PKA and PKC (Ki values are 21 and 42 μM, respectively). Cell-permeable. Inhibits tumor cell growth.
  • 纯度> 99%

性能

  • 化学名称Hexahydro-1-[(5-Iodo-1-naphthaleny)sulfonyl]-1H-1,4-diazepine hydrochloride
  • 分子量452.74
  • 化学结构Chemical Structure
  • 分子式C15H17IN2O2S.HCl
  • CAS编号110448-33-4
  • 存放说明Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解度概述Soluble in DMSO to 100 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • 来源

    Synthetic

  • 研究领域

    ML7 (ab120848)参考文献

    This product has been referenced in:
    • Barkan D  et al. Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton. Cancer Res 68:6241-50 (2008). Read more (PubMed: 18676848) »
    • Petrache I  et al. Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction. Am J Physiol Lung Cell Mol Physiol 280:L1168-78 (2001). Read more (PubMed: 11350795) »
    • Zhou FQ & Cohan CS Growth cone collapse through coincident loss of actin bundles and leading edge actin without actin depolymerization. J Cell Biol 153:1071-84 (2001). Read more (PubMed: 11381091) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"