概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human
    • 序列
      C-VTKEESEKEQTAVET
    • 氨基酸
      195 to 209

技术指标

Our Abpromise guarantee covers the use of ab45735 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • E3 ubiquitin-protein ligase makorin-1
    • FLJ21334
    • HGNC:7112
    • Makorin
    • Makorin ring finger protein 1
    • MKRN 1
    • mkrn1
    • MKRN1_HUMAN
    • OTTHUMP00000212117
    • OTTHUMP00000212118
    • OTTHUMP00000212121
    • OTTHUMP00000212124
    • Ring finger protein 1
    • RING finger protein 61
    • RNF61
    see all
  • 功能
    E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.
  • 组织特异性
    Ubiquitous.
  • 通路
    Protein modification; protein ubiquitination.
  • 序列相似性
    Contains 4 C3H1-type zinc fingers.
    Contains 1 RING-type zinc finger.
  • 翻译后修饰
    Auto-ubiquitinated; which leads to proteasomal degradation.
  • Information by UniProt

文献

ab45735 has not yet been referenced specifically in any publications.

客户评价及客户问答

There are currently no Customer reviews or Questions for ab45735.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册