Anti-PDK1抗体(ab90444)
Key features and details
- Rabbit polyclonal to PDK1
- Suitable for: WB
- Reacts with: Mouse, Rat, Rabbit, Dog, Human, Pig, African green monkey
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-PDK1抗体
参阅全部 PDK1 一抗 -
描述
兔多克隆抗体to PDK1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Rat, Rabbit, Dog, Human, Pig, African green monkey -
免疫原
Synthetic peptide corresponding to Human PDK1 conjugated to keyhole limpet haemocyanin.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.09% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab90444于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/1000. Predicted molecular weight: 49 kDa.
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说明 |
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WB
1/1000. Predicted molecular weight: 49 kDa. |
靶标
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功能
Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism. -
组织特异性
Expressed predominantly in the heart. -
序列相似性
Belongs to the PDK/BCKDK protein kinase family.
Contains 1 histidine kinase domain. -
细胞定位
Mitochondrion matrix. - Information by UniProt
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数据库链接
- Entrez Gene: 5163 Human
- Entrez Gene: 228026 Mouse
- Entrez Gene: 100286871 Pig
- Entrez Gene: 116551 Rat
- Omim: 602524 Human
- SwissProt: Q15118 Human
- SwissProt: Q8BFP9 Mouse
- SwissProt: Q63065 Rat
see all -
别名
- [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial antibody
- HGNC:8809 antibody
- Mitochondrial pyruvate dehydrogenase kinase isoenzyme 1 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (8)
ab90444 被引用在 8 文献中.
- Wang H et al. PD-L1, PDK-1 and p-Akt are correlated in patients with papillary thyroid carcinoma. Adv Clin Exp Med 29:785-792 (2020). PubMed: 32750756
- Hong SM et al. Lactic acidosis caused by repressed lactate dehydrogenase subunit B expression down-regulates mitochondrial oxidative phosphorylation via the pyruvate dehydrogenase (PDH)-PDH kinase axis. J Biol Chem 294:7810-7820 (2019). PubMed: 30923124
- Pendleton AL et al. Increased pyruvate dehydrogenase activity in skeletal muscle of growth-restricted ovine fetuses. Am J Physiol Regul Integr Comp Physiol 317:R513-R520 (2019). PubMed: 31314546
- Shibao S et al. Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model. Neuro Oncol 20:343-354 (2018). PubMed: 29016888
- Gudiksen A et al. Training state and fasting-induced PDH regulation in human skeletal muscle. Pflugers Arch N/A:N/A (2018). PubMed: 29946822
- Bertholdt L et al. Impact of skeletal muscle IL-6 on regulation of liver and adipose tissue metabolism during fasting. Pflugers Arch 470:1597-1613 (2018). PubMed: 30069669
- Gudiksen A et al. Muscle interleukin-6 and fasting-induced PDH regulation in mouse skeletal muscle. Am J Physiol Endocrinol Metab 312:E204-E214 (2017). PubMed: 28028037
- Gudiksen A et al. Lack of Skeletal Muscle IL-6 Affects Pyruvate Dehydrogenase Activity at Rest and during Prolonged Exercise. PLoS One 11:e0156460 (2016). WB . PubMed: 27327080