Anti-MiTF (phospho S73)抗体(ab59201)

概述

  • 产品名称Anti-MiTF (phospho S73)抗体
    参阅全部 MiTF 一抗
  • 描述
    兔多克隆抗体to MiTF (phospho S73)
  • 特异性Detects endogenous levels of MiTF only when phosphorylated at serine 73.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic phosphopeptide (Human) from around the phosphorylation site of serine 73 (PNSPPM)

  • 阳性对照
    • Cos 7 cell extract

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab59201 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明ELISA: 1/5000.
    WB: 1/500 - 1/1000. Detects a band of approximately 59 kDa (predicted molecular weight: 59 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Transcription factor for tyrosinase and tyrosinase-related protein 1. Binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') found in the tyrosinase promoter. Plays a critical role in the differentiation of various cell types as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
    • 组织特异性Isoform M is exclusively expressed in melanocytes and melanoma cells. Isoform A and isoform H are widely expressed in many cell types including melanocytes and retinal pigment epithelium (RPE). Isoform C is expressed in many cell types including RPE but not in melanocyte-lineage cells.
    • 疾病相关Defects in MITF are the cause of Waardenburg syndrome type 2A (WS2A) [MIM:193510]. It is a dominant inherited disorder characterized by sensorineural hearing loss and patches of depigmentation. The features show variable expression and penetrance.
      Defects in MITF are a cause of Waardenburg syndrome type 2 with ocular albinism (WS2-OA) [MIM:103470]. It is an ocular albinism with sensorineural deafness.
      Defects in MITF are the cause of Tietz syndrome (TIETZS) [MIM:103500]. It is an autosomal dominant disorder characterized by generalized hypopigmentation and profound, congenital, bilateral deafness. Penetrance is complete.
    • 序列相似性Belongs to the MiT/TFE family.
      Contains 1 basic helix-loop-helix (bHLH) domain.
    • 翻译后修饰Phosphorylation at Ser-405 significantly enhances the ability to bind the tyrosinase promoter.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • BHLHE32 antibody
      • bHLHe32 antibody
      • Class E basic helix-loop-helix protein 32 antibody
      • CMM8 antibody
      • Homolog of mouse microphthalmia antibody
      • Mi antibody
      • Microphthalmia associated transcription factor antibody
      • Microphthalmia, mouse, homolog of antibody
      • Microphthalmia-associated transcription factor antibody
      • MITF antibody
      • MITF_HUMAN antibody
      • mitfa antibody
      • nacre antibody
      • WS2 antibody
      • WS2A antibody
      • z3A.1 antibody
      see all

    Anti-MiTF (phospho S73) antibody 图像

    • All lanes : Anti-MiTF (phospho S73) antibody (ab59201) at 1/500 dilution

      Lane 1 : Cos 7 cell extract
      Lane 2 : Cos 7 cell extract with phosphopeptide


      Predicted band size : 59 kDa
      Observed band size : 59 kDa

    Anti-MiTF (phospho S73) antibody (ab59201)参考文献

    ab59201 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab59201.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"