Mirin,MRN-ATM complex抑制剂(ab141182)
Key features and details
- MRN-ATM complex inhibitor
- CAS Number: 299953-00-7
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Mirin,MRN-ATM complex抑制剂 -
描述
MRN-ATM complex抑制剂 -
生物学描述
Mre11-Rad50-Nbs1 (MRN)-ATM complex inhibitor that blocks the 3' to 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC50= 12 μM) and induces G2 arrest in vitro.
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纯度
> 99% -
CAS编号
299953-00-7 -
化学结构
性能
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化学名称
2-Amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone -
分子量
220.25 -
分子式
C10H8N2O2S -
PubChem识别号
1206243 -
存放说明
Store at +4°C. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C2NC(=N)S/C2=C\c1ccc(O)cc1 -
来源
Synthetic
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研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (2)
ab141182 被引用在 2 文献中.
- Petsalaki E & Zachos G An ATM-Chk2-INCENP pathway activates the abscission checkpoint. J Cell Biol 220:N/A (2021). PubMed: 33355621
- Isobe SY et al. Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action. Cell Rep 36:109383 (2021). PubMed: 34260925