The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and rat Mint 3 protein, catalog ab3450. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.
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Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Adapter protein X11gamma
amyloid beta (A4) precursor protein binding, family A, member 3
Amyloid beta A4 precursor protein-binding family A member 3
Amyloid beta precursor protein binding, family A, member 3 phosphotyrosine binding/ interacting domain (PTB) bearing protein
Neuron specific X11L2 protein
Neuron-specific X11L2 protein
Neuronal Munc18 1 interacting protein 3
Neuronal Munc18-1-interacting protein 3
phosphotyrosine binding/interacting domain (PTB) bearing protein
X11 like 2 protein 2
功能May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.
组织特异性Expressed in all tissues examined with lower levels in brain and testis.
结构域Composed of an N-terminal domain, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.