Milnacipran hydrochloride (ab120755)

概述

  • 产品名称Milnacipran hydrochloride
  • 描述
    Serotonin and norepinephrine reuptake inhibitor
  • 生物学描述Serotonin and norepinephrine reuptake inhibitor. IC50 values are 100, 203 and >100000 nM for NA, 5-HT and DA, respectively. Centrally active following oral administration. Exhibits antidepressant and antifibromyalgia activity in vivo.
  • 纯度> 99%

性能

    应用

    Our Abpromise guarantee covers the use of ab120755 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    应用 Ab评论 说明
    Functional Studies Use at an assay dependent concentration.

    Milnacipran hydrochloride 图像

    • ab113202 staining NET1 in PC-12 cells treated with milnacipran hydrochloride (ab120755), by ICC/IF. Decrease of NET1 expression correlates with increased concentration of milnacipran hydrochloride, as described in literature.
      The NGF treated cells were incubated at 37°C for 6 hour in media containing different concentrations of ab120755 (milnacipran hydrochloride ) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab113202 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    Milnacipran hydrochloride (ab120755)参考文献

    This product has been referenced in:
    • Uchida M  et al. Intranasal administration of milnacipran in rats: evaluation of the transport of drugs to the systemic circulation and central nervous system and the pharmacological effect. Biol Pharm Bull 34:740-7 (2011). Read more (PubMed: 21532166) »
    • Puozzo C  et al. Pharmacology and pharmacokinetics of milnacipran. Int Clin Psychopharmacol 17 Suppl 1:S25-35 (2002). Read more (PubMed: 12369608) »
    • Moret C  et al. Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (Z) hydrochloride, a potential fourth generation antidepressant drug. Neuropharmacology 24:1211-9 (1985). Read more (PubMed: 3005901) »

    See 0 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120755.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"