Anti-MICB抗体[MM0473-3C37] (ab90237)

概述

  • 产品名称Anti-MICB抗体[MM0473-3C37]
    参阅全部 MICB 一抗
  • 描述
    小鼠单克隆抗体[MM0473-3C37] to MICB
  • 经测试应用适用于: WB, Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length Human MICB.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered.
  • 克隆单克隆
  • 克隆编号MM0473-3C37
  • 同种型IgG2b
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab90237 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 43 kDa.
Flow Cyt 1/20 - 1/200. ab170192-Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
  • 组织特异性Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue.
  • 疾病相关Genetic variations in MICA are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Note=The MICB*004 allele is associated with rheumatoid arthritis.
    Note=Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk.
  • 序列相似性Belongs to the MHC class I family. MIC subfamily.
    Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • 翻译后修饰Proteolytically cleaved and released from the cell surface of tumor cells.
  • 细胞定位Cell membrane. Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MHC class I chain related protein B2 antibody
    • MHC class I mic B antigen antibody
    • MHC class I polypeptide related sequence B antibody
    • MHC class I polypeptide-related sequence B antibody
    • MIC B antibody
    • MIC-B antibody
    • MICB antibody
    • MICB_HUMAN antibody
    • PERB11.2 antibody
    see all

Anti-MICB antibody [MM0473-3C37] (ab90237)参考文献

ab90237 has not yet been referenced specifically in any publications.

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