Anti-MICA + MICB抗体[6D4] (FITC) (ab46529)

概述

  • 产品名称Anti-MICA + MICB抗体[6D4] (FITC)
    参阅全部 MICA + MICB 一抗
  • 描述
    小鼠单克隆抗体[6D4] to MICA + MICB (FITC)
  • 偶联物FITC. Ex: 493nm, Em: 528nm
  • 特异性This antibody is specific for non classical MICA and non classical MICB.
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    MICA transfected C1R cells.

  • 常规说明


    This antibody is reported to inhibit the cytotoxicity of NK cells stimulated by IFN alpha-treated dendritic cells.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein G purified
  • Primary antibody说明This antibody is reported to inhibit the cytotoxicity of NK cells stimulated by IFN alpha-treated dendritic cells.
  • 克隆单克隆
  • 克隆编号6D4
  • 同种型IgG2a
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab46529 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 10µl for 106 cells. ab91362-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
  • 组织特异性Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassal's corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells.
  • 疾病相关Anti-MICA antibodies and ligand shedding are involved in the progression of monoclonal gammopathy of undetermined significance (MGUS)to multiple myeloma.
    Psoriasis 1
    Psoriatic arthritis
  • 序列相似性Belongs to the MHC class I family. MIC subfamily.
    Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • 翻译后修饰N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation.
    Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and T-cell activation.
  • 细胞定位Cell membrane. Cytoplasm. Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MHC class I chain-related protein A antibody
    • MHC class I chain-related protein B antibody
    • MHC class I polypeptide related sequence A antibody
    • MHC class I polypeptide related sequence B antibody
    • MHC class I polypeptide-related sequence A antibody
    • MIC-A antibody
    • micA antibody
    • MICA_HUMAN antibody
    • MICB antibody
    see all

Anti-MICA + MICB antibody [6D4] (FITC) (ab46529)参考文献

ab46529 has not yet been referenced specifically in any publications.

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