概述

  • 产品名称Mibefradil dihydrochloride
  • 描述
    Ca2+ channel blocker
  • 生物学描述Ca2+ channel blocker. Shows moderate selectivity for T-type channels (IC50 values are 2.7 and 18.6 μM for T-type and L-type respectively). Shows antihypertensive effects in vivo. Orally active.
  • 纯度> 98%

性能

    Mibefradil dihydrochloride (ab120343)参考文献

    This product has been referenced in:
    • Wang J  et al. Ca(2+) influx mediates the TRPV4-NO pathway in neuropathic hyperalgesia following chronic compression of the dorsal root ganglion. Neurosci Lett 588:159-65 (2015). Read more (PubMed: 25575793) »
    • Fernández-Morales JC  et al. Blockade by NNC 55-0396, mibefradil, and nickel of calcium and exocytotic signals in chromaffin cells: implications for the regulation of hypoxia-induced secretion at early life. Eur J Pharmacol 751:1-12 (2015). Read more (PubMed: 25622555) »
    • Osterrieder W & Holck M In vitro pharmacologic profile of Ro 40-5967, a novel Ca2+ channel blocker with potent vasodilator but weak inotropic action. J Cardiovasc Pharmacol 13:754-9 (1989). Read more (PubMed: 2472524) »

    See all 3 Publications for this product

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