生物素Anti-MHC class II I E kappa抗体[14-4-4S] (ab93504)
Key features and details
- Biotin Mouse monoclonal [14-4-4S] to MHC class II I E kappa
- Suitable for: Flow Cyt
- Reacts with: Mouse, Rat
- Conjugation: Biotin
- Isotype: IgG2a
Related conjugates and formulations
概述
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产品名称
生物素Anti-MHC class II I E kappa抗体[14-4-4S]
参阅全部 MHC class II I E kappa 一抗 -
描述
生物素小鼠单克隆抗体[14-4-4S] to MHC class II I E kappa -
宿主
Mouse -
偶联物
Biotin -
特异性
ab93504 reacts with the mouse and rat MHC Class II, I-E subregion-encoded glycoprotein in mice strains of H-2k, H-2d, H-2p and H-2r. H-2f and H-2s haplotypes do not express the I-E antigen. -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Mouse, Rat -
免疫原
This product was produced with the following immunogens:
Tissue, cells or virus corresponding to Mouse MHC class II I E kappa. C3H mouse skin graft
Tissue, cells or virus corresponding to Mouse MHC class II I E kappa. Mouse splenocytes -
阳性对照
- Mouse splenocytes
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常规说明
The 14-4-4S monoclonal antibody has been reported to block antigen presentation in in vitro assays.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.09% Sodium azide
Constituents: 0.87% Sodium chloride, PBS -
Concentration information loading...
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纯度
Protein G purified -
Primary antibody说明
The 14-4-4S monoclonal antibody has been reported to block antigen presentation in in vitro assays. -
克隆
单克隆 -
克隆编号
14-4-4S -
同种型
IgG2a -
轻链类型
kappa -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab93504于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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Flow Cyt |
Use at an assay dependent concentration.
ab18454 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
说明 |
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Flow Cyt
Use at an assay dependent concentration. ab18454 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
靶标
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相关性
A major histocompatibility complex class II receptor. These display processed antigens from virally infected or transformed cells. Class II positive cells ('antigen presenting cells') can take up antigens from outside by endocytosis, degrade them into small peptides, and re export the peptides (now bound to MHC class II protein) to the cell surface. These peptide MHC class II complexes can then be recognized by specific CD4+ lymphocytes. -
细胞定位
Type I membrane protein -
别名
- H2 Ea antibody
- H2-Ea antibody
数据表及文件
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Datasheet download
文献 (4)
ab93504 被引用在 4 文献中.
- Spencer JS et al. Expression and function of mixed isotype MHC class II molecules in normal mice. J Immunol 151:6822-32 (1993). PubMed: 8258692
- Pruitt SK et al. The effect of xenoreactive antibody and B cell depletion on hyperacute rejection of guinea pig-to-rat cardiac xenografts. Transplantation 56:1318-24 (1993). PubMed: 8278996
- Liu H et al. Immune T cells sorted by flow cytometry confer protection against infection with Treponema pallidum subsp. pertenue in hamsters. Infect Immun 58:1685-90 (1990). PubMed: 2187804
- Maloy WL et al. Evidence for the association of I-A and I-E molecules in d-haplotype mice. Mol Immunol 23:263-9 (1986). PubMed: 3459016