概述

  • 产品名称
    Anti-MHC class I RT Ia抗体[OX-18]
    参阅全部 MHC class I RT Ia 一抗
  • 描述
    小鼠单克隆抗体[OX-18] to MHC class I RT Ia
  • 特异性
    Ab33752 recognises a monomorphic determinant of rat MHC Class I (RT1A), expressed by all rat strains. However, quantitative measurements suggest that not all of the class I molecules are recognised.
  • 经测试应用
    适用于: Flow Cyt, ELISA, IHC-Fr, IPmore details
  • 种属反应性
    与反应: Rat
  • 免疫原

    Rat spleen glycoproteins.

  • 常规说明


    This clone (OX-18) has been used in immunoaffinity purification of rat MHC class I molecules.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液
    Preservative: 0.09% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 纯度
    Protein G purified
  • 纯化说明
    This antibody was purified tissue culture supernatant.
  • Primary antibody说明
    This clone (OX-18) has been used in immunoaffinity purification of rat MHC class I molecules.
  • 克隆
    单克隆
  • 克隆编号
    OX-18
  • 骨髓瘤
    P3x63-Ag8.653
  • 同种型
    IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab33752 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt 1/10 - 1/50.

Use 10µl of this dilution for 106 cells in 100µl.





ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
ELISA Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.

Acetone fixation recommended. The antigen is sensitive to fixation with paraformaldehyde.

IP Use at an assay dependent concentration.

靶标

  • 相关性
    The major histocompatibility complex (MHC) plays a central role in controlling immune responsiveness and susceptibility to a great variety of mainly autoimmune and infectious diseases. The mammalian MHC is usually divided into three regions, the class I, II, and III (also called central) gene regions, based on the genes contained therein. Class I regions encode the classical I (class Ia) and nonclassical I (class Ib) molecules. The widely expressed class Ia molecules perform the well described antigen presenting function to CD8 T lymphocytes, whereas the function of class Ib genes has largely remained unknown.
  • 细胞定位
    Secreted
  • 数据库链接
  • 别名
    • RT1 class I gene (A 1) antibody
    • RT1 class I gene antibody
    • RT1 class Ia locus A antibody
    • RT1 class Ia, locus A (A1) antibody
    • RT1 class Ia, locus A1 antibody
    • RT1.A1(N) antibody
    • RT1A 1 antibody
    • RT1A1 antibody
    see all

Anti-MHC class I RT Ia antibody [OX-18] (ab33752)参考文献

This product has been referenced in:
  • Heuer A  et al. hESC-derived neural progenitors prevent xenograft rejection through neonatal desensitisation. Exp Neurol 282:78-85 (2016). IHC ; Rat . Read more (PubMed: 27235932) »
  • Smits KM  et al. Preincubation of tumor cells with the anti-(MHC) class I antibody OX18 enhances tumor cell lysis by interleukin-2-activated NK cells. Transplant Proc 25:2806-7 (1993). Read more (PubMed: 8212242) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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