Anti-Metabotropic Glutamate Receptor 6抗体(ab83576)


  • 产品名称Anti-Metabotropic Glutamate Receptor 6抗体
    参阅全部 Metabotropic Glutamate Receptor 6 一抗
  • 描述
    兔多克隆抗体to Metabotropic Glutamate Receptor 6
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Cow, Dog, Pig, Chimpanzee
  • 免疫原

    Synthetic peptide corresponding to a region within the N terminal amino acids 35-84 (AGGLTLGGLF PVHARGAAGR ACGQLKKEQG VHRLEAMLYA LDRVNADPEL) of Human Metabotropic Glutamate Receptor 6 (NP_000834).

  • 阳性对照
    • 721_B cell lysate.



Our Abpromise guarantee covers the use of ab83576 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 33, 95 kDa (predicted molecular weight: 95 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay 1/312500.


  • 功能Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.
  • 疾病相关Defects in GRM6 are the cause of congenital stationary night blindness type 1B (CSNB1B) [MIM:257270]. This disorder consits of a previously unrecognized, autosomal recessive form of congenital night blindness associated with a negative electroretinogram waveform. Patients are night blind from an early age, and when maximally dark-adapted, they could perceive lights only with an intensity equal to or slightly dimmer than that normally detected by the cone system. ERGs in response to single brief flashes of light have clearly detectable a-waves, which are derived from photoreceptors, and greatly reduced b-waves, which are derived from the second-order inner retinal neurons. ERGs in response to sawtooth flickering light indicate a markedly reduced ON response and a nearly normal OFF response. There is no subjective delay in the perception of suddenly appearing white vs black objects on a gray background.
  • 序列相似性Belongs to the G-protein coupled receptor 3 family.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CSNB1B antibody
    • DKFZp686H1993 antibody
    • GluR6 antibody
    • Glutamate receptor metabotropic 6 antibody
    • GPRC1F antibody
    • Grm6 antibody
    • GRM6_HUMAN antibody
    • Metabotropic glutamate receptor 6 antibody
    • mGlu6 antibody
    • mGluR6 antibody
    see all

Anti-Metabotropic Glutamate Receptor 6 antibody 图像

  • Anti-Metabotropic Glutamate Receptor 6 antibody (ab83576) at 1 µg/ml + 721_B cell lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 95 kDa
    Observed band size : 33,95 kDa (why is the actual band size different from the predicted?)

Anti-Metabotropic Glutamate Receptor 6 antibody (ab83576)参考文献

ab83576 has not yet been referenced specifically in any publications.

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