Anti-Metabotropic Glutamate Receptor 6抗体(ab10314)

概述

  • 产品名称
    Anti-Metabotropic Glutamate Receptor 6抗体
    参阅全部 Metabotropic Glutamate Receptor 6 一抗
  • 描述
    兔多克隆抗体to Metabotropic Glutamate Receptor 6
  • 经测试应用
    适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Rat
  • 免疫原

    Synthetic peptide:

    AAPPQNENAEDAK

    , corresponding to C terminal amino acids 859-871 of Rat Metabotropic Glutamate Receptor 6.

  • 阳性对照
    • Rat retina.
  • 常规说明


    L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.1% Sodium Azide
    Constituents: 0.1% BSA, Tris-glycine
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • Primary antibody说明
    L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab10314 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2000 - 1/3000. Predicted molecular weight: 105.2 kDa.
ICC/IF 1/300.

靶标

  • 功能
    Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.
  • 疾病相关
    Defects in GRM6 are the cause of congenital stationary night blindness type 1B (CSNB1B) [MIM:257270]. This disorder consits of a previously unrecognized, autosomal recessive form of congenital night blindness associated with a negative electroretinogram waveform. Patients are night blind from an early age, and when maximally dark-adapted, they could perceive lights only with an intensity equal to or slightly dimmer than that normally detected by the cone system. ERGs in response to single brief flashes of light have clearly detectable a-waves, which are derived from photoreceptors, and greatly reduced b-waves, which are derived from the second-order inner retinal neurons. ERGs in response to sawtooth flickering light indicate a markedly reduced ON response and a nearly normal OFF response. There is no subjective delay in the perception of suddenly appearing white vs black objects on a gray background.
  • 序列相似性
    Belongs to the G-protein coupled receptor 3 family.
  • 细胞定位
    Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CSNB1B antibody
    • DKFZp686H1993 antibody
    • GluR6 antibody
    • Glutamate receptor metabotropic 6 antibody
    • GPRC1F antibody
    • Grm6 antibody
    • GRM6_HUMAN antibody
    • Metabotropic glutamate receptor 6 antibody
    • mGlu6 antibody
    • mGluR6 antibody
    see all

图片



  • Predicted band size : 105.2 kDa


    ab10314 at 1/1000 dilution staining rat metabotropic Glutamate Receptor 6 by Western blot. Left image: Metabotropic Glutamate Receptor 6 transfected cells. Right image: Rat retina.
  • Staining of mouse nob rescue retinal sections using ab10314

文献

ab10314 has not yet been referenced specifically in any publications.

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