Anti-Metabotropic Glutamate Receptor 5b抗体(ab125261)

概述

  • 产品名称Anti-Metabotropic Glutamate Receptor 5b抗体
    参阅全部 Metabotropic Glutamate Receptor 5b 一抗
  • 描述
    兔多克隆抗体to Metabotropic Glutamate Receptor 5b
  • 经测试应用适用于: WB, IP, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Rat, Human
  • 免疫原

    Synthetic peptide derived from the C terminus of Human Metabotropic Glutamate Receptor 5b. This sequence is identical to Human and Rat.

  • 阳性对照
    • Human brain tissue.

性能

应用

Our Abpromise guarantee covers the use of ab125261 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 1 µg/ml. Predicted molecular weight: 132 kDa.
IP Use a concentration of 2 - 5 µg/ml.
ELISA Use a concentration of 0.01 - 0.1 µg/ml.
IHC-P 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 相关性Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: Ionotropic receptors, and metabotropic receptors (mGluRs). Metabotropic Glutamate Receptor 5b (GRM5) activity is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The metabotropic glutamate receptor type 5 (mGlu5) is expressed in two splice variants, mGlu5a and mGlu5b, which differ in that mGlu5b has a 33-amino acid insert in the intracellular C-terminal domain. This receptor subtype is highly regulated, with higher levels found in developing animals.
  • 细胞定位Cell Membrane
  • 数据库链接
  • 别名
    • Glutamate receptor, metabotropic 5 antibody
    • GPRC1E antibody
    • GRM5 antibody
    • metabotropic glutamate receptor 5 antibody
    • Metabotropic glutamate receptor 5 variant F antibody
    • Metabotropic glutamate receptor 5 variant G antibody
    • Metabotropic glutamate receptor 5 variant H antibody
    • mGlu5 antibody
    • mGluR5 antibody
    • MGLUR5B antibody
    see all

Anti-Metabotropic Glutamate Receptor 5b antibody 图像

  • ab125261 at 1/50 dilution, for 10 minutes at RT, staining Metabotropic Glutamate Receptor 5b in Formalin-Fixed Human brain tissue by Immunohistochemistry.

Anti-Metabotropic Glutamate Receptor 5b antibody (ab125261)参考文献

ab125261 has not yet been referenced specifically in any publications.

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