Anti-Metabotropic Glutamate Receptor 3抗体(ab10309)

概述

  • 产品名称Anti-Metabotropic Glutamate Receptor 3抗体
    参阅全部 Metabotropic Glutamate Receptor 3 一抗
  • 描述
    兔多克隆抗体to Metabotropic Glutamate Receptor 3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Rat
    预测可用于: Mouse, Human
  • 免疫原

    Synthetic peptide:

    TKVDEAEYM

    , corresponding to amino acids 118-126 of Rat metabotropic Glutamate Receptor 3.

  • 阳性对照
    • Rat Cerebellar and cortical Membrane.
  • 常规说明


    L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.1% Sodium Azide
    Constituents: 1.0% BSA, Tris-glycine. pH 7.8
  • 纯度Whole antiserum
  • Primary antibody说明L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab10309 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 105.2 kDa. Using standard protocols the antibody has only been shown to work in systems using highly expressing transfected cells.

靶标

Anti-Metabotropic Glutamate Receptor 3 antibody 图像



  • Predicted band size : 105.2 kDa


    ab10309 at 1/1000 dilution by Western blot. Left image: rat cerebellar membrane. Right image: rat cortical membrane.

Anti-Metabotropic Glutamate Receptor 3 antibody (ab10309)参考文献

This product has been referenced in:
  • García-Bea A  et al. Metabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: Antibody characterisation and a semi-quantitative western blot study. Schizophr Res N/A:N/A (2016). WB . Read more (PubMed: 27130562) »

See 1 Publication for this product

Product Wall

Thank you for your enquiry. Testing has shown that this antibody does not cross react with mGluR2. Please contact us again if you require further assistance.

Yes. By Carl Romano's group and the antibody is specific for mGluR3.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"